Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8)

1. The ZnT8 Arg325Trp polymorphism has been linked to heightened inflammation in type 2 diabetes. PMID: 30142362
2. This study investigated the impact of the interaction between ZNT8 rs13266634 and dietary factors on the risk of metabolic syndrome. PMID: 28490771
3. HLA-A*24, the SLC30A8 T allele, and high BMI have been associated with poor graft outcomes in type 1 diabetics undergoing pancreatic islet transplantation. PMID: 29679103
4. The finding that the diabetes risk genotype C/C at SNP rs13266634 of the SLC30A8 gene encoding the beta-cell Zn transporter ZnT8 is associated with a higher total islet Zn concentration has potential clinical significance. PMID: 28352089
5. Results demonstrate that SLC30A8 rs2466293 was associated with T1D predisposition in Brazilians with non-European ancestry. PMID: 28303020
6. SLC30A8 serves as a valuable biological marker for classifying newly diagnosed diabetics. PMID: 29288641
7. Common single nucleotide polymorphisms (SNPs) contribute to type 2 diabetes risk susceptibility, and DNA methylation levels are increased in type 2 diabetes patients. [review] PMID: 26593983
8. The differential cytolocation of ZnT8 isoforms may be relevant for beta-cell zinc metabolism in both health and disease. PMID: 28965566
9. The rs13266634/T SNP (SLC30A8) is a potential protective variant against the development of gestational diabetes mellitus. PMID: 28072873
10. A high Arg-325 variant in ZnT8 is associated with an increased risk of Type-2 Diabetes. PMID: 27875315
11. The results provide strong evidence for an independent association between type 2 diabetes mellitus and SNPs in TCF7L2 and SLC30A8. PMID: 27310578
12. This study is the first to report a significant association between the R325W C-allele of SLC30A8 and an increased risk of developing gestational diabetes mellitus. Notably, all of the autoantibody-positive women with GDM who developed postpartum type 1 diabetes were positive for autoantibodies against glutamic acid decarboxylase. This suggests that ZnT8A did not have any additional predictive value in the postpartum development of type 1 diabetes. PMID: 27003436
13. While previous meta-analyses indicated that this association was primarily observed in Asian and European groups, not in African populations, our analysis revealed a deleterious effect of SLC30A8 rs13266634 on type 2 diabetes mellitus in an African population when stratified by ethnicity under an additive model, even with a small number of studies. PMID: 26832344
14. Results suggest a lack of association between the SLC30A8 SNPs and type 2 diabetes in Mexican American families. PMID: 27896278
15. The hZnT8 R325W transgenic line exhibited lower pancreatic [Zn(2+)]i and proinsulin, and higher insulin and glucose tolerance compared to control littermates after 10 weeks of a high-fat diet in male mice. Conversely, the hZnT8 WT transgenic line demonstrated the opposite, and dietary Zn(2+) supplementation also induced glucose intolerance. PMID: 27899481
16. Data indicate that gestational weight gain may modify the impact of SLC30A8 variants on long-term glycemic changes, highlighting the importance of controlling gestational weight for the prevention of postpartum hyperglycemia in women with GDM. PMID: 27600066
17. We investigated the association of the polymorphisms rs13266634 (SLC30A8) in a case-control study of Euro-Brazilians with gestational diabetes. The minor allele frequencies for the T-allele (SLC30A8 gene rs13266634) were 27.8% (95%CI = 23-32%) for healthy individuals and 23.5% (95%CI = 18-29%) for those with gestational diabetes, P = 0.227. Genotype comparisons showed no significant difference. PMID: 28363002
18. Two miR-binding SNPs, SLC30A8 rs2466293 and INSR rs1366600, were associated with an increased susceptibility to gestational diabetes mellitus. Functional studies are needed to confirm the underlying mechanism. PMID: 28190110
19. We successfully constructed a T1D phage display antibody library and identified two ZnT8-specific scFv clones, C27 and C22. These ZnT8-specific scFvs have potential as agents in immunodiagnostic and immunotherapy for T1D. PMID: 27270580
20. The results obtained for ZnT8A measurement using ELISA were consistent with previous data. Such investigation could improve risk stratification and be integrated into daily practice. PMID: 27363941
21. Detection of ZnT8 antibodies in blood precedes the detection of classical islet antibodies in children at risk of developing diabetes mellitus type 1. PMID: 26824044
22. Studies indicate that individuals with specific mutations in the SLC30A8 gene (Solute carrier family 30, member 8) are 65% less likely to develop diabetes. PMID: 26957571
23. Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk PMID: 26214053
24. Analysis of the size and direction of the effect of SLC30A8 risk alleles in humans. PMID: 25287711
25. Zinc supplementation appears to affect the early insulin response to glucose differentially by rs13266634 genotype and could potentially be beneficial for diabetes prevention and/or treatment in certain individuals based on SLC30A8 variation. PMID: 25348609
26. Data suggest that the rs3019885 SLC30A8 SNP is not a susceptibility factor for abdominal aortic aneurysms in an Italian population. PMID: 24423473
27. These data demonstrate that T1D patients may possess single amino acid-specific autoantibodies targeting either ZnT8R or ZnT8W, and the autoantibody affinity to the respective variant may differ. PMID: 25178386
28. Homologous epitopes of zinc transporter 8 and MAP3865c are recognized by individuals with Hashimoto's thyroiditis from Sardinia. PMID: 24830306
29. The rs13266634 polymorphism might play a significant role in lipid metabolism and cardiovascular risk in HIV/hepatitis C-coinfected patients. PMID: 24499956
30. No significant difference was found between normal and diabetic subjects regarding the rs13266634 C/T polymorphism in the SLC30A8 gene. PMID: 24449369
31. Both common and rare genetic variation in SLC30A8 are associated with measures of beta-cell function in the Diabetes Prevention Program. PMID: 24471563
32. Our study suggested that the C allele of rs13266634 was associated with higher odds of T2D, and higher plasma zinc levels were associated with lower odds. The inverse association of plasma zinc concentrations with T2D was modified by SLC30A8 rs13266634. PMID: 24306209
33. Antibodies for ZnT8 are related to age and metabolic status at diagnosis, as well as HLA genotype, but do not significantly improve the detection rate of beta-cell autoimmunity in Finnish children and adolescents affected by Type 1 diabetes. PMID: 23861236
34. SLC30A8 haploinsufficiency protects against type 2 diabetes, suggesting ZnT8 inhibition as a potential therapeutic strategy for type 2 diabetes prevention. PMID: 24584071
35. Men with two copies of the allele that protects against type 2 diabetes showed less post-exercise bout strength loss, reduced soreness, and lower creatine kinase values. PMID: 24101675
36. Homologous epitopes of zinc transporter 8 and MAP3865c are recognized at the onset of T1D in Sardinian children. PMID: 23696819
37. ZnT8A was more prevalent and persistent in patients with LADA compared to adult-onset type 1 diabetes, but its presence was not associated with specific phenotypic characteristics. PMID: 23194113
38. SLC30A8 regulates hepatic insulin clearance. PMID: 24051378
39. Analysis of ZnT8A increased the diagnostic sensitivity of islet autoantibodies for T1D, as only 7% remained islet autoantibody negative. The association between DQ6.4 and all three ZnT8A may be related to ZnT8 antigen presentation by the DQ6.4 heterodimer. PMID: 22957668
40. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes. PMID: 23396399
41. ZnT8-specific CD4(+) T cells are skewed towards Th1 cells in type 1 diabetes mellitus patients. PMID: 23390544
42. Carriers of the TT genotype of the SLC30A8 gene predict lower stimulated C-peptide levels 12 months after type 1 diabetes diagnosis. PMID: 22686132
43. The humoral autoreactivity to ZnT8 depends on the clinical phenotype, which may provide insights into the role of this protein in the pathogenesis of type 1 diabetes. PMID: 22447136
44. The SLC30A8 gene variation does not appear to contribute to a genetic basis for the co-occurrence of schizophrenia and T2DM. PMID: 22778022
45. At diagnosis of type 1 diabetes in non-Swedes, the presence of ZnT8-RA autoantibodies rather than ZnT8-WA was likely due to effects of HLA-DQ2 and the SLC30A8 genotypes. PMID: 22787139
46. Data conclude that type 2 diabetes is associated with the AA genotype of rs11558471 in the human SLC30A8 gene. PMID: 22653633
47. ZNT8 expression responds to variations in zinc and lipid levels in human beta cells, with repercussions on insulin secretion. PMID: 22582094
48. ZnT8A testing, in combination with other autoantibodies, facilitates disease prediction, even though the biomarker is not under the same genetic control as the disease. PMID: 22526605
49. ZnT8-reactive CD8(+) T cells are directed against the ZnT8(186-194) epitope and are detected in a majority of IDDM patients. The exceptional immunodominance of ZnT8(186-194) may point to common environmental triggers that precipitate beta cell autoimmunity. PMID: 22526607
50. ZnT8A identified a subset at a higher diabetes risk. ZnT8A predicted diabetes independently of ICA, the standard BAA, age, and HLA type. ZnT8A should be included in type 1 diabetes prediction and prevention studies. PMID: 22446173

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HGNC: 20303

OMIM: 125853

KEGG: hsa:169026

STRING: 9606.ENSP00000415011

UniGene: Hs.532270