Recombinant Legionella pneumophila DNA repair protein recO (recO)
Description
Research Implications and Gaps
While recO is critical for bacterial DNA repair, its specific role in Legionella pathogenesis or survival within host cells remains unexplored. Key gaps include:
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Mechanistic Studies: No peer-reviewed data exist on recO’s interaction with host DNA repair machinery or its contribution to bacterial persistence.
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Functional Analogs: The RecBCD pathway in Legionella may share functional similarities with E. coli, but strain-specific differences are unconfirmed.
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Antimicrobial Targets: Potential exploitation of recO for therapeutic development (e.g., disrupting DNA repair in biofilm formation) is speculative without experimental validation.
Comparative Analysis of DNA Repair Proteins in Legionella
Future Directions
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Biochemical Characterization: Assess recO’s ATPase activity, single-stranded DNA (ssDNA) binding, and interaction with RecB/RecD.
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Pathogenesis Studies: Investigate recO’s role in surviving oxidative stress or host immune evasion.
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Therapeutic Potential: Explore inhibitors targeting recO to disrupt bacterial DNA repair in Legionella-infected cells.
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your format preference during order placement for customized preparation.
Note: Our proteins are shipped with standard blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
The tag type will be determined during the production process. If you require a specific tag, please inform us, and we will prioritize its development.
Target Background
KEGG: lpf:lpl0974
