Recombinant Lemur catta Hemoglobin subunit beta (HBB)
Shipped with Ice Packs 
In Stock 
Description
Applications in Research
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Disease Modeling: Mutations in HBB cause beta-thalassemia, sickle cell anemia, and methemoglobinemia .
Genetic Disorders
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Sickle Cell Anemia: Caused by Glu6Val substitution, leading to hemoglobin polymerization and erythrocyte sickling .
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Beta-Thalassemia: Reduced or absent beta-globin synthesis causes ineffective erythropoiesis and anemia .
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Methemoglobinemia: Variants like HbM disrupt heme-iron stability, impairing oxygen binding .
Therapeutic Developments
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Gene Editing: CRISPR-based replacement of alpha-globin with beta-globin has shown promise in restoring hemoglobin balance in beta-thalassemia models .
Limitations and Ethical Considerations
Product Specs
Form
Lyophilized powder. We will ship the format we have in stock. If you have specific format requirements, please note them when ordering.
Lead Time
Delivery times vary by purchasing method and location. Contact your local distributor for specific delivery times. All proteins are shipped with blue ice packs by default. Contact us in advance for dry ice shipping (extra fees apply).
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Briefly centrifuge the vial before opening. Reconstitute protein in sterile deionized water to 0.1-1.0 mg/mL. Add 5-50% glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%.
Shelf Life
Shelf life depends on storage conditions, buffer ingredients, temperature, and protein stability. Liquid form: 6 months at -20°C/-80°C. Lyophilized form: 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
The tag type is determined during manufacturing. If you require a specific tag, please inform us, and we will prioritize its development.
Synonyms
HBB; Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-146
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Lemur catta (Ring-tailed lemur)
Target Names
Target Protein Sequence
TFLTPEENGH VTSLWGKVNV EKVGGEALGR LLVVYPWTQR FFESFGDLSS PDAIMGNPKV
KAHGKKVLSA FSEGLHHLDN LKGTFAQLSE LHCVALHVDP ENFKLLGNVL VIVLAHHFGN
DFSPQTQAAF QKVVTGVANA LAHKYH
Uniprot No.
Target Background
Function
Involved in oxygen transport from the lungs to peripheral tissues.
Protein Families
Globin family
Tissue Specificity
Red blood cells.
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