Recombinant Lucilia cuprina FMRFamide-13

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Cat. No.

BT45720

Source

Yeast

Synonyms

FMRFamide-13; LucFMRFamide-13

Purity

>85% (SDS-PAGE)

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Cat. No.

BT45720

Source

E.coli

Synonyms

FMRFamide-13; LucFMRFamide-13

Purity

>85% (SDS-PAGE)

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Cat. No.

BT45720

Source

E.coli

Synonyms

FMRFamide-13; LucFMRFamide-13

Purity

>85% (SDS-PAGE)

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Cat. No.

BT45720

Source

Baculovirus

Synonyms

FMRFamide-13; LucFMRFamide-13

Purity

>85% (SDS-PAGE)

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Cat. No.

BT45720

Source

Mammalian cell

Synonyms

FMRFamide-13; LucFMRFamide-13

Purity

>85% (SDS-PAGE)

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Description

Role of FMRFamide-Related Peptides

FMRFamides in Lucilia cuprina and other insects regulate stress responses, feeding behavior, and reproductive processes . For example:

In Caenorhabditis elegans, FMRFamide-like peptides (e.g., FLP-13) induce quiescence during heat stress by activating ALA neurons .
In L. cuprina, neuropeptidomics studies identified 45 peptides, including FMRFamide-related molecules, highlighting their diversity in physiological regulation .

Applications in Research

Stress Response Studies: Recombinant FMRFamide-13 could serve as a tool to investigate peptide-receptor interactions in stress-induced quiescence .
Pest Control: While not directly tested, FMRFamide analogs may inform strategies to disrupt blowfly behavior or reproduction .

Comparisons and Variants

Recombinant FMRFamide-13 is available in multiple formats, each with distinct advantages:

Expression System	Advantages	Limitations
Baculovirus	High yield; suitable for insect protein studies	Requires specialized equipment
E. coli	Cost-effective; rapid production	Risk of improper folding
Yeast	Eukaryotic post-translational modifications	Lower throughput
Mammalian Cells	Native-like glycosylation (if applicable)	High cost

Mitochondrial and Genomic Context

While not directly related to FMRFamide-13, mitochondrial genomic studies of L. cuprina subspecies reveal high AT content (77.7%) and distinct clades, underscoring the species’ genetic diversity . This context supports the use of L. cuprina as a model for studying peptide evolution and function .

Challenges and Considerations

Sequence Variability: The discrepancy between GPSQDFMRF (recombinant) and APSQDFMRF (synthetic) necessitates careful verification of product specifications .
Functional Specificity: FMRFamide-13 may share receptor binding sites with other FaRPs, complicating functional studies .

Product Specs

Form

Lyophilized powder. We will ship the available format, but you can specify your preferred format when ordering.

Lead Time

Delivery times vary. Contact your local distributor for specifics. Proteins are shipped with blue ice packs by default; request dry ice in advance (extra fees apply).

Notes

Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.

Reconstitution

Briefly centrifuge the vial before opening. Reconstitute in sterile deionized water to 0.1-1.0 mg/mL. Add 5-50% glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%.

Shelf Life

Shelf life depends on storage conditions, buffer, temperature, and protein stability. Liquid form: 6 months at -20°C/-80°C. Lyophilized form: 12 months at -20°C/-80°C.

Storage Condition

Store at -20°C/-80°C upon receiving. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.

Tag Info

Tag type is determined during manufacturing. Specify your preferred tag type during ordering, and we will prioritize its development.

Synonyms

FMRFamide-13; LucFMRFamide-13

Buffer Before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Datasheet

Please contact us to get it.

Expression Region

1-9

Protein Length

Cytoplasmic domain

Purity

>85% (SDS-PAGE)

Species

Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)

Target Protein Sequence

GPSQDFMRF

Uniprot No.

P85457

Target Background

Protein Families

FARP (FMRFamide related peptide) family

Subcellular Location

Secreted.

Tissue Specificity

Detected in the thoracic perisympathetic organs in larvae, and the dorsal ganglionic sheath in adults (at protein level).

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Recombinant Lucilia cuprina FMRFamide-13

Description

Role of FMRFamide-Related Peptides

Applications in Research

Comparisons and Variants

Mitochondrial and Genomic Context

Challenges and Considerations

Product Specs

Target Background

Quick Inquiry

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