Recombinant Meriones unguiculatus Monocarboxylate transporter 2 (SLC16A7)
Description
Production and Purification
The recombinant protein is produced via E. coli expression systems, optimized for high yield and stability . Post-purification steps involve Tris-based buffers with 50% glycerol to maintain solubility and functionality during storage at -20°C or -80°C .
Cancer Metabolism Studies
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MCT2 overexpression is linked to tumor progression in prostate and breast cancers, driven by epigenetic deregulation (e.g., promoter demethylation) .
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Recombinant MCT2 enables in vitro studies on lactate shuttling in cancer microenvironments, particularly in models exploring metabolic crosstalk between adipocytes and carcinoma cells .
Neurological Research
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MCT2 supports oligodendrocyte function by importing lactate and ketone bodies for myelin maintenance. Knockdown studies in mice highlight its role in preventing axonal degeneration .
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The gerbil variant may aid comparative studies of species-specific transporter efficiency .
Antibody Development
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Anti-MCT2 antibodies (e.g., Boster Bio A05214) utilize recombinant proteins as immunogens for Western blot validation in human and rat models .
Future Directions
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Targeted Therapies: MCT2 inhibition is being explored to disrupt cancer metabolic pathways .
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Neurodegenerative Diseases: Recombinant MCT2 could model therapeutic strategies for multiple sclerosis, given its role in oligodendrocyte metabolism .
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Structural Biology: Cryo-EM studies using recombinant MCT2 may resolve substrate-binding dynamics and guide drug design.
Product Specs
Note: We prioritize shipping the format readily available in our inventory. However, if you have specific format requirements, please indicate them during order placement. We will accommodate your requests as possible.
Note: All our proteins are standardly shipped with normal blue ice packs. If you require dry ice shipping, please inform us in advance, as additional fees will apply.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
