Recombinant Mouse Amino acid transporter heavy chain SLC3A2 (Slc3a2)
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In Stock 
Product Specs
Buffer
Lyophilized from Tris/PBS-based buffer, containing 6% Trehalose, pH 8.0.
Form
Available in both liquid and lyophilized powder formats.
Note: We prioritize shipping the format currently in stock. However, if you have a specific format requirement, please indicate it when placing your order, and we will accommodate your request.
Note: We prioritize shipping the format currently in stock. However, if you have a specific format requirement, please indicate it when placing your order, and we will accommodate your request.
Lead Time
Generally, we can ship products within 1-3 working days of receiving your order. Delivery times may vary depending on the purchase method or location. Please consult your local distributors for specific delivery timelines.
Note: All our proteins are shipped with standard blue ice packs. If dry ice shipping is required, please inform us in advance, as additional fees will apply.
Note: All our proteins are shipped with standard blue ice packs. If dry ice shipping is required, please inform us in advance, as additional fees will apply.
Notes
Avoid repeated freezing and thawing. For multiple use, store working aliquots at 4°C for up to one week.
Shelf Life
Shelf life is influenced by various factors, including storage conditions, buffer composition, temperature, and the protein's inherent stability.
Generally, liquid forms have a shelf life of 6 months at -20°C/-80°C, while lyophilized forms maintain their stability for 12 months at -20°C/-80°C.
Generally, liquid forms have a shelf life of 6 months at -20°C/-80°C, while lyophilized forms maintain their stability for 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple use. Repeated freeze-thaw cycles should be avoided.
Tag Info
N-terminal 10xHis-tagged
Synonyms
Slc3a2; Mdu1; 4F2 cell-surface antigen heavy chain; 4F2hc; Solute carrier family 3 member 2; CD antigen CD98
Datasheet & Coa
Please contact us to get it.
Expression Region
1-526
Protein Length
full length protein
Species
Mus musculus (Mouse)
Target Names
Target Protein Sequence
MSQDTEVDMKDVELNELEPEKQPMNAADGAAAGEKNGLVKIKVAEDETEAGVKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPVQRWWHKGALYRIGDLQAFVGRDAGGIAGLKSHLEYLSTLKVKGLVLGPIHKNQKDEINETDLKQINPTLGSQEDFKDLLQSAKKKSIHIILDLTPNYQGQNAWFLPAQADIVATKMKEALSSWLQDGVDGFQFRDVGKLMNAPLYLAEWQNITKNLSEDRLLIAGTESSDLQQIVNILESTSDLLLTSSYLSNSTFTGERTESLVTRFLNATGSQWCSWSVSQAGLLADFIPDHLLRLYQLLLFTLPGTPVFSYGDELGLQGALPGQPAKAPLMPWNESSIFHIPRPVSLNMTVKGQNEDPGSLLTQFRRLSDLRGKERSLLHGDFHALSSSPDLFSYIRHWDQNERYLVVLNFRDSGRSARLGASNLPAGISLPASAKLLLSTDSARQSREEDTSLKLENLSLNPYEGLLLQFPFVA
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Uniprot No.
Target Background
Function
SLC3A2 (Slc3a2), also known as amino acid transporter heavy chain, is a component of several heterodimeric complexes involved in amino acid transport. The precise substrate specificity of these complexes is determined by the other subunit within the heterodimer. These complexes function as amino acid exchangers. The SLC3A2 homodimer acts as a sodium-independent, high-affinity transporter responsible for the uptake of large neutral amino acids like phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine, and tryptophan. When partnered with SLC7A6 or SLC7A7, SLC3A2 forms a heterodimer responsible for the uptake of dibasic amino acids. Its heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones, triiodothyronine (T3) and thyroxine (T4), across the cell membrane. The heterodimer with SLC7A5/LAT1 is implicated in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, as well as in the uptake of leucine. In association with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes, promoting leucine uptake into these organelles and consequently mediating mTORC1 activation. The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier. The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, facilitated by the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. In conjunction with ICAM1, SLC3A2 regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals. It is essential for the targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for their channel activity. SLC3A2 also plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via L-arginine transport and may mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier.
Gene References Into Functions
- Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway. PMID: 30451822
- Slc3a2 is required for branched-chain amino-acid-dependent maintenance of Treg cells. PMID: 29141216
- CD98hc expression in vascular smooth muscle cells contributes to the formation of plaques that are morphologically more stable, and thereby protects against atherothrombosis. PMID: 28012647
- These results demonstrate a novel fundamental role of LAT1 to support the protein expression of 4F2hc via a chaperone-like function in chorionic trophoblasts. PMID: 28320871
- CD98 is required for endothelial cell growth. CD98-specific reagents could have a dual anticancer effect: directly by inhibiting tumor cell proliferation and indirectly by preventing tumor angiogenesis PMID: 27687603
- Taken together, our data indicate that T cell-specific deletion of CD98hc can contribute to the prevention of GvHD development due to the attenuation of lymphocyte migration and by increasing the generation of Treg cells. PMID: 26836475
- data establish CD98hc as a master protective gene at the cross-road of redox control and AA availability, making it a relevant therapeutic target in cancer. PMID: 26945935
- ubiquitylation and the resulting downregulation of CD98 can limit cell proliferation and clonal expansion. PMID: 26493331
- CD98hc mediated this stiffness sensing by increasing Rho kinase (ROCK) activity. PMID: 25267066
- Mice lacking CD98hc in B cells are protected from experimental autoimmune encephalomyelitis. PMID: 25002078
- CD98 heavy chain is crucial for T cell-mediated autoimmune colitis. CD98 heavy chain deficiency in T cells is involved in increasing induced regulatory T cells. PMID: 24491544
- The role of SLC3A2 in keratinocytes is not in cell adhesion but, instead, in cell proliferation and migration through modulating integrin signaling by the Src-RhoA pathway. PMID: 23296466
- CD98-dependent amino acid transport increased renal tubular epithelial cell proliferation is mediated by Erk and p38 MAPK signaling. PMID: 22768207
- Investigated the contribution of CD98 to intestinal tumorigenesis in Apc(Min/+) mice and the underlying mechanism of action. PMID: 22641098
- when the CD98hc deficient macrophages were stimulated with either IFN-gamma/LPS or IL-4, the production of NO(2) or arginase-I decreased in comparison to that observed in the control macrophages PMID: 22624878
- T cell-specific deficiency in CD98hc can contribute to cardiac allograft permanent acceptance correlating with the attenuation of lymphocyte migration and by increasing the generation of regulatory T cells. PMID: 22588539
- Taken together, these observations show that the combination of an inflammatory context and intestinal epithelial cell expression of CD98 affects the regulation of miRNA expression in colonic epithelial and immune cells. PMID: 22499850
- CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice PMID: 21490400
- Exogenous putrescine is transported into gastrointestinal tract by caveolin-1- and NOS2-dependent mechanisms. Solute carrier transporter SLC3A2 can function bidirectionally to import putrescine under conditions of low tissue polyamines. PMID: 20522643
- CD98 molecules are essential for mouse embryogenesis PMID: 12927796
- CD98 stimulation by anti-CD98 antibodies induced CEA-CAM-1-mediated cell adhesion PMID: 14527684
- Results demonstrate that xCT is a new member of the proteins whose transcriptional control by the amino acid deprivation is mediated by the amino acid response element. PMID: 15522208
- CD98 is a scaffolding protein that interacts with basolaterally expressed amino acid transporters and beta1 integrins and can alter amino acid transport and cell adhesion, migration and branching morphogenesis PMID: 15713750
- Results suggest that the CD98 system is independent of the interleukin-2/IL-2R system in murine T lymphocyte activation. PMID: 16707844
- the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates PMID: 17273864
- identified critical integrin residues required for CD98hc interaction that CD98c interaction with the integrin beta tail is required for its ability to mediate integrin signaling. PMID: 17597067
- CD98hc expression can vary widely; the data show that these variations in CD98hc expression can control the capacity of cells to assemble a fibronectin matrix, a process important in development, wound healing, and tumorigenesis. PMID: 17682053
- Reconstitution of CD98hc-deficient B cells with CD98hc mutants showed that the integrin-binding domain of CD98hc was required for B cell proliferation but that the amino acid-transport function of CD98hc was dispensable for this. PMID: 19270713
- These studies establish the importance of CD98hc in VSMC proliferation and survival. PMID: 19841087
Database Links
Protein Families
SLC3A transporter family
Subcellular Location
Apical cell membrane. Cell membrane; Single-pass type II membrane protein. Cell junction. Lysosome membrane. Melanosome.
Tissue Specificity
Detected on the surface of embryonic epithelial cells in the epidermis, thymus, kidney, intestine, brain choroid plexus, and in retina. Detected in adult and embryonic brain, spleen, kidney, intestine and liver, and in adult testis (at protein level). Obs
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