Recombinant mouse Cldnd2 is commercially available in multiple formats:
Table 1: Recombinant Mouse Cldnd2 Products
Catalog #
Source/Host
Tag
Protein Length
Price Range*
Supplier
Cldnd2-2182M
HEK293
Myc/DDK
Full-length
$500–$800
Creative BioMart
RFL7515MF
E. coli
His
Full-length
$600–$900
Creative BioMart
NM_028849
Mammalian systems
Customizable
Variable
$400–$1,200
OriGene Technologies
*Pricing estimates based on industry standards for recombinant proteins.
Table 2: Key Experimental Uses
Application
Example Study
Outcome
Protein Interaction
Yeast two-hybrid, co-IP
Identified binding partners in tight junction pathways
In Vivo Delivery
AAV-CMV-Cldnd2 vector (abm, Cat. No. 16291104)
Enables transient overexpression in murine models
Diagnostic Assays
ELISA, Western blot (ThermoFisher control fragment)
Validated for specificity in biomarker studies
Challenges and Opportunities
Specificity: Antibodies against Cldnd2 require rigorous validation due to homology with other claudins.
Therapeutic Potential: While claudin-2 fusion proteins show promise in HIV neutralization, Cldnd2’s role in disease remains underexplored.
Tool Development: The AAV-Cldnd2 vector (serotype-dependent) facilitates gene delivery but requires optimization for target tissues.
Product Specs
Form
Lyophilized powder Note: We will prioritize shipping the format currently in stock. However, if you have specific format requirements, please indicate them in your order notes. We will prepare the product according to your request.
Lead Time
Delivery time may vary depending on the purchasing method and location. Please consult your local distributors for specific delivery timeframes. Note: All our proteins are shipped with standard blue ice packs by default. If dry ice shipping is required, please contact us in advance. Additional fees will apply.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Reconstitution
We recommend centrifuging the vial briefly before opening to ensure the contents settle to the bottom. Reconstitute the protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend adding 5-50% glycerol (final concentration) and aliquoting for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%, which can serve as a reference.
Shelf Life
Shelf life is influenced by various factors, including storage conditions, buffer ingredients, storage temperature, and the protein's inherent stability.
Generally, the shelf life of the liquid form is 6 months at -20°C/-80°C. The shelf life of the lyophilized form is 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquoting is necessary for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production. If you have a specific tag type requirement, please inform us, and we will prioritize developing the specified tag.