Recombinant Mouse Mas-related G-protein coupled receptor member E (Mrgpre)
Description
Overview
Recombinant Mouse Mas-related G-protein coupled receptor member E (Mrgpre) is a laboratory-engineered protein that replicates the native Mrgpre receptor found in mice. Mrgpre belongs to the Mas-related G protein-coupled receptor (MRGPR) family, which is involved in sensory signaling, immune responses, and neuro-immune interactions . The recombinant form enables controlled studies of its structure, ligand interactions, and functional roles in vitro and in vivo.
Functional Insights
Mrgpre is implicated in sensory and immune modulation:
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Heterodimerization: Rat Mrgpre forms functional heterodimers with Mrgprd, altering β-alanine-induced calcium signaling and receptor internalization .
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Ligand specificity: MRGPRs broadly recognize diverse ligands (e.g., peptides, small molecules), but Mrgpre’s endogenous ligands are not fully characterized.
Research Applications
Recombinant Mrgpre is critical for:
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Ligand screening: Identifying agonists/antagonists via binding assays.
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Mechanistic studies: Resolving activation pathways and crosstalk with other receptors (e.g., Mrgprd) .
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Disease models: Investigating roles in itch, pain, and mast cell-mediated inflammation .
Challenges and Future Directions
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Structural data: No high-resolution structures of Mrgpre exist, hindering mechanistic insights .
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Ligand identification: Endogenous ligands for Mrgpre remain unidentified, unlike MRGPRX2 (activated by basic secretagogues) .
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Species differences: Human MRGPRE lacks direct rodent orthologs, complicating translational studies .
Product Specs
Note: We prioritize shipping the format currently in stock. However, if you have a specific format requirement, please indicate it in your order notes. We will fulfill your request if possible.
Note: All our proteins are shipped with standard blue ice packs. If you require dry ice shipping, please inform us in advance. Additional charges will apply.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Target Background
- Research suggests that MrgE plays a role in specific pain behavioral responses in mice. PMID: 18197975
KEGG: mmu:244238
UniGene: Mm.183561
