Recombinant Mouse Nexilin (Nexn)
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized fulfillment.
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized fulfillment.
Lead Time
Delivery times vary depending on the purchase method and location. Contact your local distributor for precise delivery estimates.
Note: All proteins are shipped with standard blue ice packs unless dry ice is specifically requested in advance. Additional fees apply for dry ice shipping.
Note: All proteins are shipped with standard blue ice packs unless dry ice is specifically requested in advance. Additional fees apply for dry ice shipping.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Centrifuge the vial briefly before opening to collect the contents. Reconstitute the protein in sterile deionized water to a concentration of 0.1-1.0 mg/mL. For long-term storage, we recommend adding 5-50% glycerol (final concentration) and aliquoting at -20°C/-80°C. Our default glycerol concentration is 50% and can be used as a guideline.
Shelf Life
Shelf life depends on storage conditions, buffer composition, temperature, and protein stability. Generally, liquid formulations have a 6-month shelf life at -20°C/-80°C, while lyophilized formulations have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquoting is essential for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing.
The tag type will be determined during the production process. Please specify your desired tag type for prioritized development.
The tag type will be determined during the production process. Please specify your desired tag type for prioritized development.
Synonyms
Nexn; Nexilin; F-actin-binding protein
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-607
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Mus musculus (Mouse)
Target Names
Nexn
Target Protein Sequence
MNDVSQKAEI KEMLASDDEE ESSPKIEKAY VPKLTGTVKG KFDEMEKHRQ EEQRKRTEEE
RKRRIEQDLL EKRKIQRELA KRAEQIEDIN NTGTESASEE GDDSLLITVV PAKSYKTPGK
TKDPEDLDRE EGNGRTNHEE DKMRYEEECR VLKEAKCLSL VMDDETEAKK ESHFPGKLKS
TFEELERQRQ ENRKKQAEEE ARRRLEEERR SFEEARRHMV NEEDENQDRE TVFKEYRPGK
LKLSFEEIER QRREDEKRKA EEEARRRIEE EKAAFAEARR SMVLDDDSPE IYKTVSQESL
TPGKLEINFE QLLRQKMEEE RRRTEEERRH KLEMEKQEFE QLRQEMGKEE EENESFGLSR
EYEELIKLKR SGSIQAKNLK SKFEKIGQLS EKEVQKKIEE ERAKRRAIDL EIKEREAENF
HEDDDVDVRP AKKSESPFTH KVNMKARFEQ MAKAREEEEQ RRIEEQKLLR MQFEQKEIDA
ALQKKREDEE EEEGSIVNGS TTEDEEQTRS GAPWFKKPLR NTSVVDSEPV RFTVKVTGEP
KPEITWWFEG EILQDGEDYQ YIERGETYCL YLPETFPEDG GEYMCKAVNN KGSAASTCIL
TIEMDDY
Uniprot No.
Target Background
Function
Nexilin regulates cell migration by interacting with the actin cytoskeleton and plays a crucial role in maintaining Z-line and sarcomere integrity.
Gene References Into Functions
- Studies highlight Nexilin's role in dilated cardiomyopathy and suggest a novel function in endomyocardial fibroelastosis. PMID: 26659360
- Nexilin is identified as a novel gene associated with atrial septal defect (ASD), and its function in inhibiting GATA4 reveals a critical regulatory mechanism involving an F-actin binding protein and a transcription factor in cardiac development. PMID: 24866383
Database Links
Subcellular Location
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cytoplasm, myofibril, sarcomere, Z line.
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
