Recombinant Mouse Olfactory receptor 498 (Olfr498)
Description
Functional Insights
Olfr498 operates within the canonical olfactory signaling pathway:
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Odorant Binding: Interacts with specific volatile molecules via distinct residues in transmembrane domains .
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G-protein Activation: Couples with guanine nucleotide-binding proteins (e.g., Gα(olf), Gβ₁γ₁₃) to initiate cAMP signaling .
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Signal Termination: Mediated by β-arrestins (Arrb1/2) and GPCR kinases (Grk2/3) .
Key functional studies include:
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Heterologous Expression: Systems like HEK293 cells enable odorant response profiling. For example, related ORs (e.g., Olfr538, Olfr524) show dose-dependent activation to ligands like (R)-carvone and heptanal .
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In Vivo Modulation: Chronic odorant exposure alters Olfr498 mRNA levels, suggesting activity-dependent regulation .
Interaction Network
Olfr498 forms a functional network with signaling partners identified via proteomic analyses :
Table 2: Key Interaction Partners
| Protein | Role in Olfactory Signaling |
|---|---|
| Gα(olf) | Activates adenylate cyclase |
| β-arrestin | Mediates receptor desensitization |
| GRK2/3 | Phosphorylates activated receptors |
| Vmn1r183 | Co-expressed vomeronasal receptor |
Research Applications
Recombinant Olfr498 is critical for:
Product Specs
Note: While we prioritize shipping the format currently in stock, we are happy to accommodate specific format requirements. Please indicate your preference in the order notes, and we will prepare the product accordingly.
Note: All proteins are shipped with standard blue ice packs. Should you require dry ice shipping, please communicate this need in advance. Additional fees will apply.
Generally, liquid forms have a shelf life of 6 months at -20°C/-80°C. Lyophilized forms typically exhibit a shelf life of 12 months at -20°C/-80°C.
