Recombinant Mouse Palmitoyltransferase ZDHHC18 (Zdhhc18)
Description
Functional Role in Research
ZDHHC18 is implicated in regulating innate immunity by palmitoylating cyclic GMP-AMP synthase (cGAS), a DNA sensor. Key findings from studies using recombinant ZDHHC18 include:
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Mechanistic Insight:
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ZDHHC18-mediated palmitoylation at cGAS residue C474 inhibits cGAS/DNA complex formation, suppressing cGAS dimerization and downstream immune signaling .
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Overexpression of ZDHHC18 reduces cGAMP production and IRF3 phosphorylation, confirming its role as a negative regulator of the cGAS-STING pathway .
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Experimental Applications:
Related Products and Variants
Recombinant ZDHHC18 is available in multiple formats for diverse experimental needs:
| Product ID | Species | Tag | Application |
|---|---|---|---|
| RFL21794MF | Mouse | His | Enzyme kinetics, structural studies |
| ZDHHC18-10314M | Mouse | His-Fc-Avi | Protein interaction assays |
| RFL6037RF | Rat | His | Cross-species comparative studies |
Research Implications
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Therapeutic Targets: ZDHHC18’s regulatory role in cGAS activation highlights its potential as a drug target for autoimmune diseases and viral infections .
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Tool Development: Recombinant ZDHHC18 enables high-throughput screening of palmitoylation inhibitors or activators, as seen in cadmium chloride studies .
Technical Considerations
Product Specs
Note: We prioritize shipping the format we have in stock. However, if you have specific format requirements, please indicate them when placing your order. We will fulfill your request if possible.
Note: All our proteins are shipped with standard blue ice packs. If you require dry ice shipping, please inform us in advance, as additional fees will apply.
Generally, liquid forms have a shelf life of 6 months at -20°C/-80°C. Lyophilized forms have a shelf life of 12 months at -20°C/-80°C.
