Recombinant Mouse Protein FAM163B (Fam163b), partial
Description
Overview of Recombinant Mouse Protein FAM163B (Fam163b), Partial
Recombinant Mouse Protein FAM163B (Fam163b), partial is a truncated version of the FAM163B protein, a member of the family with sequence similarity 163 (FAM163). This protein is expressed in recombinant systems to study its structure, function, and biological roles. The partial designation indicates that it lacks certain regions compared to the full-length protein, potentially focusing on functional domains critical for research applications.
Gene Expression and Regulation
FAM163B has been studied in murine models, particularly in the hippocampus. A 2021 study identified Fam163b as one of several genes downregulated in hippocampal tissues under pro-inflammatory conditions, suggesting a potential link to neuronal health .
Gene Expression Data (Hippocampus):
| Gene Symbol | RPKM | Fold Change (FC) | p-value |
|---|---|---|---|
| Fam163b | 52.3 | −1.306 | 0.00959 |
This downregulation aligns with reduced expression of genes associated with neuronal function, such as Arc, Egr1, and Nr4a1, in the same study .
Biochemical Characterization
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Protein Interactions: No direct interactions have been reported, but its expression in neuronal tissues suggests roles in cellular stress responses or signaling pathways .
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Disease Association: While not directly implicated in pathologies, its downregulation in inflammatory contexts may warrant further investigation in neurodegenerative or immune-related disorders .
Comparative Analysis of Recombinant Products
Recombinant FAM163B variants differ by host systems and expression regions:
| Product | Host | Purity | Key Features |
|---|---|---|---|
| Recombinant Mouse FAM163B (partial) | E. coli/Yeast | ≥85% | Partial sequence, SDS-PAGE validated |
| Recombinant Human FAM163B | Mammalian | ≥85% | Full-length, cell-free expression |
| Xenopus tropicalis FAM163B | E. coli/Yeast | ≥85% | Partial sequence, cross-species use |
Limitations and Future Directions
Current research on FAM163B is hindered by:
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Limited Functional Data: No experimental evidence for molecular functions (e.g., enzymatic activity, subcellular localization) .
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Partial Sequence Constraints: The truncated nature of recombinant FAM163B may limit studies on full-length interactions.
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Species-Specific Insights: Most data derive from murine models; human or other species-specific studies are lacking .
Future studies should prioritize:
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Functional Assays: Testing interactions with known neuronal or inflammatory pathways.
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Structural Analysis: Determining the role of missing regions in the partial protein.
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Cross-Species Comparisons: Validating findings in human or other model organisms.
Product Specs
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