Recombinant Mouse Protein FAM48A (Fam48a)
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized preparation.
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized preparation.
Lead Time
Delivery times vary depending on the purchasing method and location. Please contact your local distributor for precise delivery estimates.
Note: Our proteins are shipped with standard blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
Note: Our proteins are shipped with standard blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Centrifuge the vial briefly before opening to collect the contents. Reconstitute the protein in sterile, deionized water to a concentration of 0.1-1.0 mg/mL. For long-term storage, we recommend adding 5-50% glycerol (final concentration) and aliquoting at -20°C/-80°C. Our standard glycerol concentration is 50%, but this can be adjusted as needed.
Shelf Life
Shelf life depends on various factors including storage conditions, buffer composition, temperature, and protein stability. Generally, liquid forms have a 6-month shelf life at -20°C/-80°C, while lyophilized forms have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses to prevent repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing.
The tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
The tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
Synonyms
Supt20h; D3Ertd300e; Fam48a; Supt20; Transcription factor SPT20 homolog; p38-interacting protein; p38IP
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-530
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Mus musculus (Mouse)
Target Names
Target Protein Sequence
MQQAVEQALD CAEYIVESAQ QRPPKRKYLS SGRKSIFQKL YDLYVEECEK EPEVKKLRRN
VNLLEKLVMQ ETLSCLVVNL YPGNEGYSLM LRGKNGSDSE TIRLPYEEGE LLEYLDAEEL
PPILVDLLEK SQVNIFHCGC VIAEIRDYRQ SSNMKSPGYQ SRHILLRPTM QTLVCDVHSI
TSDNHKWTQE DKLLLESQLI LATAEPLCLD PSVAVACTAN RLLYNRQKMN TRPMKRCWKR
YSRSSLNRQQ DLSHGPPPPQ LRLLDFLQKR KERKAGQHYD LKISKAGNCV DMWKRSPCNL
AVPSEVDVEK YAKVEESIKS DDSQPTMWPA HDVKDDYVFE CEGGNQYQKT KLTILQSLGD
PLYYGKIQPW KADEENDSQM SPSHSSADDH SNWFVIGSKT DAERVVNQYQ ELVQNEAKCP
VKMSHSSSGS AALSPGEEAE QAETSSIQSS VLGKGVKHRP PPIKLPSGSG NSSSGNYFTA
QQASSFLKSP TPPPSCKPSL SRKSSVDLSQ VSMLSPAALS PASSSQRHES
Uniprot No.
Target Background
Function
FAM48A is essential for p38 MAP kinase (MAPK11, MAPK12, MAPK13, and/or MAPK14) activation during gastrulation. It plays a crucial role in downregulating E-cadherin during gastrulation by modulating E-cadherin protein levels downstream of NCK-interacting kinase (NIK), independent of FGF signaling and Snail-mediated transcriptional regulation. Additionally, FAM48A is involved in starvation-induced ATG9A trafficking during autophagy.
Gene References Into Functions
- Gcn5 and Supt20 hypomorphs exhibit similar defects in rostral-caudal somite patterning, suggesting potential shared mechanisms. PMID: 27894818
Database Links
Protein Families
SPT20 family
Tissue Specificity
Ubiquitously expressed throughout development.
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