Recombinant Mouse Tissue factor (F3)

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Cat. No.
BT2127473
Source
in vitro E.coli expression system
Synonyms
F3; Cf-3; Cf3; Tissue factor; TF; Coagulation factor III; CD antigen CD142
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Product Specs

Form
Lyophilized powder
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order remarks for customized preparation.
Lead Time
Delivery times vary depending on the purchase method and location. Please contact your local distributor for precise delivery estimates.
Note: All proteins are shipped with standard blue ice packs unless dry ice shipping is requested in advance. Additional fees apply for dry ice shipping.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Centrifuge the vial briefly before opening to settle the contents. Reconstitute the protein in sterile, deionized water to a concentration of 0.1-1.0 mg/mL. For long-term storage, we recommend adding 5-50% glycerol (final concentration) and aliquoting at -20°C/-80°C. Our standard glycerol concentration is 50%, provided as a guideline.
Shelf Life
Shelf life depends on storage conditions, buffer composition, temperature, and protein stability. Generally, liquid formulations have a 6-month shelf life at -20°C/-80°C, while lyophilized forms have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses to prevent repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing.
The tag type is determined during production. Please specify your preferred tag type for prioritized development.
Synonyms
F3; Cf-3; Cf3; Tissue factor; TF; Coagulation factor III; CD antigen CD142
Buffer Before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Datasheet
Please contact us to get it.
Expression Region
29-294
Protein Length
Full Length of Mature Protein
Species
Mus musculus (Mouse)
Target Names
F3
Target Protein Sequence
AGIPEKAFNLTWISTDFKTILEWQPKPTNYTYTVQISDRSRNWKNKCFSTTDTECDLTDEIVKDVTWAYEAKVLSVPRRNSVHGDGDQLVIHGEEPPFTNAPKFLPYRDTNLGQPVIQQFEQDGRKLNVVVKDSLTLVRKNGTFLTLRQVFGKDLGYIITYRKGSSTGKKTNITNTNEFSIDVEEGVSYCFFVQAMIFSRKTNQNSPGSSTVCTEQWKSFLGETLIIVGAVVLLATIFIILLSISLCKRRKNRAGQKGKNTPSRLA
Uniprot No.
P20352

Target Background

Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. This [TF:VIIa] complex activates factors IX and X through specific limited proteolysis. Tissue factor (TF) plays a crucial role in normal hemostasis by initiating the assembly and propagation of the coagulation protease cascade on the cell surface.
Gene References Into Functions

Tissue Factor Function: Relevant Research

  1. Tissue factor cytoplasmic domain's role in TF-PAR-2 signaling, initiating hepatic fibrosis, and its potential as a therapeutic target due to its non-impact on coagulation. PMID: 28883694
  2. Myeloid cell-derived tissue factor's dampening effect on inflammation in acid-induced acute lung injury. PMID: 28509332
  3. Ticagrelor's (but not clopidogrel's) reduction of arterial thrombosis through endothelial tissue factor suppression, mediated by proteasomal degradation of TNF-alpha-induced TF expression. PMID: 28028070
  4. Evening primrose oil and forskolin's mitigation of celecoxib's prothrombotic effects (initiated by LPS challenge) in mice, partially through decreasing TF expression and activity. PMID: 28124089
  5. The insignificant contribution of TF on myeloid cells in multiple experimental ALI models, concluding its minor role in experimental ALI. PMID: 26924425
  6. Hepatocyte TF's activation of coagulation in a mouse model of chronic liver injury. PMID: 26325534
  7. Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease. PMID: 26817955
  8. The effect of TF expression by myeloid cells on macrophage differentiation and regulation of Mycobacterium tuberculosis growth. PMID: 26471500
  9. Tumor microparticle-expressed TF's contribution to increased cancer-associated venous thrombosis incidence in mice. PMID: 25955268
  10. A novel biological function and mechanism of the protein C pathway, where protein S and aPC-cleaved fV act as cofactors for anti-inflammatory cell signaling by aPC during endotoxemia and infection. PMID: 26341257
  11. Lung epithelial tissue factor's regulation of alveolar procoagulant activity and permeability in acute lung injury. PMID: 25884207
  12. PGE2's increase of TF expression and activity through the EP1/SIRT1 pathway. PMID: 26065856
  13. Fas-initiated, caspase-3-dependent hepatocyte apoptosis' increase of tissue factor procoagulant activity via phosphatidylserine externalization. PMID: 25015658
  14. Heme's promotion of tissue factor-dependent coagulation activation and induction of tissue factor expression on leukocytes in vivo. PMID: 25596265
  15. TF's essentiality for pericyte coverage of tumor microvessels and aPL-induced tumor cell expression of chemokine ligand 2, a pericyte recruitment mediator. PMID: 25451155
  16. Alternatively spliced tissue factor's promotion of plaque angiogenesis through activation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor signaling. PMID: 25116956
  17. A novel thrombosis protection mechanism in Klkb1(-/-) mice, involving reduced contact activation and increased receptor Mas, prostacyclin, Sirt1, and KLF4 when bradykinin delivery to vasculature is compromised. PMID: 25339356
  18. A novel mechanism for the posttranscriptional regulation of TF expression, selectively regulated by PARP-14. PMID: 25293769
  19. Delayed progression of spontaneous brain tumors in mice with TF gene disruption in the neuroectodermal lineage (oncogenic N-ras and SV40 large T antigen). PMID: 25450387
  20. The insufficiency of alternatively spliced tissue factor for embryonic development. PMID: 24879059
  21. TLR-4's contribution to arterial thrombosis formation in vivo and increased TF expression and activity in vitro. PMID: 25275013
  22. New insights into the spatiotemporal localization of prothrombinase in vivo. PMID: 24869936
  23. FVIIa's transport from circulation to extravascular tissues (where TF resides) facilitated by FVIIa binding to EPCR on the endothelium. PMID: 22950420
  24. JAK2-STAT3 signaling's regulation of TF expression. PMID: 23238822
  25. TF expression's pivotal role in MPE generation via regulation of tumor metastasis and vascular permeability in lung adenocarcinoma with activated Stat3. PMID: 24086497
  26. Tissue factor expression's provocation of escape from tumor dormancy and induction of genomic alterations. PMID: 24520174
  27. Endosomal signaling as a central coordinating point in TF expression induction. PMID: 23328933
  28. hfVII-LC and hIgG1-Fc's effective inhibition of tumor growth and metastasis in SCID mice with tissue factor (TF) over-expressing colon cancer. PMID: 23494077
  29. Tanshinone IIA's inhibition of cell proliferation and TF and MMP-12 expression in ox-LDL-stimulated RAW264.7 cells. PMID: 19620042
  30. Vascular Gas6's contribution to thrombus formation through promotion of tissue factor expression and activity. PMID: 23149844
  31. PAK1's negative regulation of TFPI and contribution to increased TF activity. PMID: 23038262
  32. The insignificant contribution of myeloid cell TF expression to venous thrombogenesis in an electrolytic injury model. PMID: 22192154
  33. Cyclooxygenase-2-derived prostacyclin's regulation of arterial thrombus formation through sirtuin-1-dependent suppression of tissue factor. PMID: 22865892
  34. Murine alternatively spliced tissue factor as a functional homolog of murine alternatively spliced tissue factor, exerting effects via beta3 integrins. PMID: 22481268
  35. A gene therapy approach for hemophilia A treatment using factor VIII (FVIII)-dual vectors. PMID: 22744182
  36. Different cellular sources of TF's contribution to coagulation activation, vascular inflammation, and endothelial cell injury in sickle cell disease. PMID: 22661702
  37. Coagulation activation only in TF-positive cell lines in nude mice, abolished by an anti-human TF antibody. PMID: 22547577
  38. Alternatively spliced tissue factor (TF) and full-length TF's protection of cardiomyocytes against TNF-alpha-induced apoptosis via activation of specific signaling pathways and upregulation of anti-apoptotic Bcl-2 proteins. PMID: 22326437
  39. Hypercholesterolemia's prothrombotic state caused by oxLDL-mediated induction of tissue factor expression in monocytes via TLR4/TLR6 complex engagement. PMID: 22214850
  40. Tissue factor's detrimental role in experimental colitis through signal transduction-dependent keratinocyte-derived chemokine production, leading to granulocyte influx and inflammation. PMID: 21717035
  41. cAMP's role in regulating tissue factor and plasminogen activator inhibitor-1 gene expression in adipocytes. PMID: 21496886
  42. Soluble alternatively spliced (as)TF's potential as a migration- and angiogenesis-promoting factor. PMID: 21389637
  43. RAR-a, RXR-a, and TF as important regulatory molecules in liver injury. PMID: 21658367
  44. Smooth muscle cells as the major source of TF in atherosclerosis without plaque rupture. PMID: 19662362
  45. Significantly elevated TF gene and protein expression in mice treated with allogenic hematopoietic stem cell transplantation. PMID: 19954621
  46. Upregulated tissue factor (TF) expression's association with age-related macular degeneration (AMD), with inflammatory and oxidative stress contributing to TF expression in AMD eyes. PMID: 21042291
  47. Tissue factor (TF) as a crucial mediator of fetal and placental damage in mouse models of recurrent miscarriages and preeclampsia. PMID: 21262438
  48. Sirt1 inhibition's induction of tissue factor expression and arterial thrombus formation in vivo. PMID: 20978007
  49. The TWEAK-Fn14 axis's regulation of TF activation and PAI-1 expression in vascular cells. PMID: 20810696
  50. Tissue factor expression's contribution to exacerbated diabetic nephropathy in eNOS-lacking mice fed a high-fat diet. PMID: 20626618
Database Links

KEGG: mmu:14066

STRING: 10090.ENSMUSP00000029771

UniGene: Mm.273188

Protein Families
Tissue factor family
Subcellular Location
Membrane; Single-pass type I membrane protein.

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