Recombinant Mouse Translocator protein (Tspo)-VLPs

1. Elevated TSPO expression signals a pro-inflammatory brain environment, not necessarily accompanied by neuronal loss. PMID: 28695372
2. The tertiary and quaternary structure of the mitochondrial translocator protein TSPO, which binds cholesterol with nanomolar affinity, is affected by cholesterol. PMID: 28358007
3. Steroidogenic abnormalities have been reported in TSPO-knockout mice, highlighting their significance in the aging male. PMID: 29127254
4. Research has shown that TSPO overexpression in the hippocampal dentate gyrus can significantly exert anxiolytic and antidepressant-like effects on behavior. These effects are associated with allopregnanolone biosynthesis, at least partially mediated by TSPO. PMID: 28655607
5. TSPO is proposed as a novel outer mitochondrial membrane-based pathway for controlling intracellular Ca(2+) dynamics and redox transients in neuronal cytotoxicity. PMID: 28640253
6. TSPO plays a critical role in steroid biosynthesis and may function, at least in part, through its regulation of DeltaPsim and effects on STAR. PMID: 29300865
7. Studies have demonstrated that TSPO and other mitophagy-related proteins, including VDAC1, Pink1, and Beclin1, are significantly decreased by LH challenge. Additionally, KIFC2, involved in mitochondrial transport, and Snap25, relevant to neurotransmitter vesicle release, are also downregulated in LH mice, further supporting evidence of existing mitochondrial dysfunction in these mice. PMID: 27543827
8. TSPO potentially plays a modulatory role in response to immune system deficiencies. PMID: 28189343
9. Increased TSPO expression has been observed in the peri-hematomal brain region following intracerebral hemorrhage. PMID: 27315802
10. TSPO expression increases significantly (approximately 9-fold) in rodent-derived macrophages and microglia upon pro-inflammatory stimulation. PMID: 28530125
11. Data suggests that upregulation of translocator protein 18kDa level during neuroinflammation might be an adaptive response mechanism, providing more neurosteroids. PMID: 27265418
12. This research confirms that TSPO deficiency does not affect viability and bronchial alveolar immune homeostasis. PMID: 27907096
13. Results indicate that Wuling powder exhibits a noticeable antidepressant effect, potentially due to the improvement of the TSPO-mediated mitophagy signaling pathway. PMID: 27063986
14. The absence of TSPO in the Central Nervous System did not result in overt developmental defects or phenotypes. The TSPO-/- mouse displayed a decrease in glial fibrillary acidic protein expression, correlating with a decrease in astrogliosis in response to neural injury during Autoimmune Experimental Encephalomyelitis. PMID: 26925573
15. This study reviews the physiological functions of the TSPO gene in the mitochondrial permeability transition pore, steroidogenesis, and energy metabolism, particularly in knockout mice. [review] PMID: 26551692
16. This study highlights the 3D structure of mTSPO/PBR and its complex with PK11195, providing an important step towards a more detailed understanding of the molecular mechanism of mammalian TSPO/PBR and its interaction with small molecules. [review] PMID: 26551694
17. TSPO expression in Sandhoff disease mice is brain region-specific and depends on the age of the animal as the disease progresses, with the thalamus providing the earliest signal of disease based on TSPO expression and other markers of neurodegeneration. PMID: 26545928
18. TSPO deficiency does not adversely affect erythropoiesis, heme biosynthesis, bioconversion of ALA to PPIX, and porphyrin-mediated phototoxic cell death. PMID: 26627829
19. TSPO can influence mitochondrial energy homeostasis through modulation of fatty acid oxidation, a function consistent with the high levels of TSPO expression observed in cell types active in lipid storage/metabolism. PMID: 26741196
20. This study determined the three-dimensional structure and side-chain dynamics of the A147T polymorph of mouse TSPO in complex with the first-generation ligand PK11195. PMID: 25974690
21. This report describes novel imidazo[1,2-a]pyridine-based TSPO ligands with potential for modulating the steroidogenesis process in murine Leydig tumor cells. PMID: 26002041
22. This study identifies TSPO as a novel element in the regulation of mitochondrial quality control by autophagy and demonstrates the importance of its expression ratio with voltage-dependent anion channel 1 for cell homeostasis. PMID: 25470454
23. TPSO knockout mice exhibit normal growth, lifespan, cholesterol transport, blood pregnenolone level, protoporphyrin IX metabolism, fertility, and behavior. Microglial activation after neuronal injury appears unimpaired, but microglia produce less ATP. PMID: 25406832
24. Data suggests that Tspo expression is closely linked to the metabolic state of adipocytes and the differentiation of preadipocytes into white/brown adipocytes. Tspo expression may improve the metabolic status of adipocytes and regulate glucose homeostasis. PMID: 26123521
25. TSPO has been found to be necessary for preimplantation embryo development and ACTH-stimulated steroid biosynthesis. PMID: 26039990
26. This study reported on the generation of TSPO-knockout MA-10 mouse Leydig tumor cells and examined their steroidogenic potential after exposure to either dibutyryl-cAMP or PK11195. PMID: 25535830
27. Data indicate that knockdown of translocator protein TSPO by siRNA had no effect on the productions of TNF-alpha, IL-1beta, and IL-6 in lipopolysaccharide (LPS)-stimulated BV-2 microglia cells. PMID: 25200148
28. TSPO upregulation in microglia occurs during neuroinflammation. PMID: 24687172
29. TSPO participates in a number of pathological processes through its actions on the PTP. PMID: 24692541
30. TSPO knock-out mice are viable with no observed effects on steroidogenesis. PMID: 24936060
31. TSPO expression can distinguish differences in the severity of myocarditis between male and female subjects. PMID: 24402571
32. A reduction in TSPO gene expression has been observed in whole tissue extracts. PMID: 24260329
33. TSPO expression in both male and female reproductive tissues is not limited to steroidogenic cells. PMID: 24040265
34. The 3D structure of TSPO in complex with its ligand PK11195 has been determined; the TSPO-PK11195 structure is characterized by a tight bundle of 5 transmembrane alpha helices forming a hydrophobic pocket that accommodates PK11195. Ligand-induced stabilization of the TSPO structure suggests a molecular mechanism for stimulating cholesterol transport into mitochondria. PMID: 24653034
35. TSPO function is not essential for steroid hormone biosynthesis. PMID: 24174323
36. TSPO expression is upregulated during microglial inflammation. PMID: 22874716
37. This study analyzes central nervous system expression and PET imaging of the translocator protein in relapsing-remitting experimental autoimmune encephalomyelitis. PMID: 23321458
38. Different amino acid compositions and the location of the polyhistidine tag between bacterial and mouse TSPO could explain the formation of dimer versus tetramer, respectively. PMID: 22771765
39. The results suggest a new micro-transcriptional mechanism regulating Tspo expression and, consequently, steroidogenesis via an intron-based SINE B2-driven natural antisense transcript specific for the Tspo gene. PMID: 22378763
40. This research examines the expression of TSPO in small rodent bone tissues. PMID: 22295097
41. Translocator protein (TSPO) expression is upregulated in cerebral regions of ob/ob leptin-deficient mice. PMID: 21299850
42. A novel androstenetriol interacts with the mitochondrial translocator protein and controls steroidogenesis. PMID: 21209087
43. The clinical consequences of secondary neuronal degeneration in stroke might be better treated by distinguishing neuronal processes using in vivo molecular imaging and potent TSPO radioligands like CLINDE to guide therapeutic interventions. PMID: 20814674
44. In conclusion, [(11)C]DAC PET responded to the change in PBR expression in tumors caused by carbon ion irradiation in this study. PMID: 19851043
45. The ability of PK11195 to suppress the pathogenesis of microphthalmia implies a critical role for mitochondrial peripheral benzodiazepine receptors in the p53-dependent mode of action of 2CdA on ocular development. PMID: 12769506
46. Two Sp1/Sp3 sites in the proximal promoter are essential for basal activity in all cell lines tested, and steroidogenic MA-10 and Y1 cells utilize different areas of the promoter compared with nonsteroidogenic NIH-3T3 cells. PMID: 14630713
47. PBR deregulation plays a role in human malignancy [isoquinoline-binding protein]. PMID: 15379570
48. Both StAR and PBR proteins are indispensable components of the steroidogenic machinery and function in a coordinated manner to transfer cholesterol into mitochondria. PMID: 15498831
49. The CRAC domain in the cytosolic carboxyl-terminal domain of PBR might be responsible for the uptake and translocation of cholesterol into the mitochondria. PMID: 15528269
50. This study is the first to show that peripheral benzodiazepine receptor and DRM/gremlin are expressed in preadipocyte cell lines and that they are differentially regulated during adipogenesis. PMID: 15919833

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KEGG: mmu:12257

STRING: 10090.ENSMUSP00000037039

UniGene: Mm.1508