Recombinant Mouse Transmembrane Protein 91, commonly referred to as Tmem91, is a multi-pass membrane protein that belongs to the Dispanin family. It is also known by other names such as SynDIG3, Dispanin subfamily C member 3, and DSPC3. Tmem91 is primarily studied for its role in cellular processes, including synapse differentiation and potentially in hematopoietic progenitor cell differentiation in humans .
Tmem91 is produced using an in vitro E. coli expression system, resulting in a lyophilized powder form. The recombinant protein is typically stored at -20°C or -80°C to maintain stability. For reconstitution, sterile deionized water is recommended, with a concentration of 0.1-1.0 mg/mL. Adding glycerol (5-50%) is suggested for long-term storage to prevent degradation.
While specific biological functions of Tmem91 are still under investigation, it is predicted to play roles in cellular differentiation and possibly in synaptic functions. In humans, Tmem91 is thought to be involved in hematopoietic progenitor cell differentiation, though detailed mechanisms remain to be elucidated .
Recombinant Tmem91 is used in various research fields, including neuroscience, immunology, and developmental biology. It serves as a valuable tool for studying membrane protein interactions and functions, particularly in the context of synaptic differentiation and cellular development.
| Characteristic | Description |
|---|---|
| Protein Length | 172 amino acids |
| Family | Dispanin family |
| Subcellular Location | Membrane; Multi-pass membrane protein |
| Synonyms | SynDIG3, DSPC3, Synapse differentiation-induced protein 3 |