Recombinant Neosartorya fumigata ATP-dependent RNA helicase dbp8 (dbp8), partial
Description
RNA Helicases and Their Functions
RNA helicases, particularly those belonging to the DEAD box family, are ATP-dependent enzymes that unwind RNA secondary structures, facilitating various cellular processes involving RNA. These enzymes are essential for the biogenesis of ribosomal subunits, where they help in the processing of pre-rRNA and the assembly of ribosomes .
| RNA Helicase | Function | Organism |
|---|---|---|
| Dbp8p | Essential for 40S ribosomal subunit biogenesis | Saccharomyces cerevisiae |
| Dbp3p | Required for 60S ribosomal subunit synthesis | Neosartorya fischeri |
Research Findings on Related RNA Helicases
While specific research on "Recombinant Neosartorya fumigata ATP-dependent RNA helicase dbp8 (dbp8), partial" is not available, studies on similar RNA helicases provide valuable insights:
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Dbp8p in Yeast: In Saccharomyces cerevisiae, Dbp8p is crucial for the early steps of pre-rRNA processing, specifically at sites A0, A1, and A2, which are necessary for the synthesis of the 18S rRNA component of the 40S ribosomal subunit .
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Dbp3p in Neosartorya fischeri: This ATP-dependent RNA helicase is involved in the synthesis of the 60S ribosomal subunit, participating in pre-rRNA processing at site A3 .
Potential Applications and Implications
Understanding the role of RNA helicases like dbp8 in Neosartorya fumigata could offer insights into fungal biology and pathogenesis. Aspergillus species, including those closely related to Neosartorya, are known pathogens that can cause severe infections in immunocompromised individuals. Research into RNA helicases could lead to the development of novel antifungal strategies by targeting essential RNA processing pathways.
References
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Characterization and mutational analysis of yeast Dbp8p, a putative RNA helicase: This study provides insights into the role of Dbp8p in ribosome biogenesis in yeast .
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ATP-dependent RNA helicase dbp3 - Neosartorya fischeri: Details the function of Dbp3p in ribosomal subunit synthesis .
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Aspergillus fumigatus RNAi machinery: Although not directly related to dbp8, this study highlights the importance of RNA processing in fungal biology .
Product Specs
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Target Background
KEGG: afm:AFUA_3G10890
STRING: 5085.CADAFUBP00003746
