Recombinant Oncorhynchus mykiss Cellular tumor antigen p53 (tp53)
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder. We will preferentially ship the format we have in stock. If you have special format requirements, please note them when ordering, and we will fulfill your request.
Lead Time
Delivery times may vary based on purchasing method and location. Consult your local distributor for specific delivery information. All proteins are shipped with standard blue ice packs. For dry ice shipping, contact us in advance; additional fees apply.
Notes
Avoid repeated freezing and thawing. Store working aliquots at 4°C for up to one week.
Reconstitution
Briefly centrifuge the vial before opening to collect contents at the bottom. Reconstitute protein in sterile deionized water to a concentration of 0.1-1.0 mg/mL. We recommend adding 5-50% glycerol (final concentration) and aliquoting for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50%.
Shelf Life
Shelf life depends on several factors: storage conditions, buffer components, storage temperature, and protein stability. Generally, the liquid form has a shelf life of 6 months at -20°C/-80°C, and the lyophilized form has a shelf life of 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
The tag type will be determined during the manufacturing process. If you have a specific tag type requirement, please inform us, and we will prioritize developing the specified tag.
Synonyms
tp53; p53; Cellular tumor antigen p53; Tumor suppressor p53
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-396
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Target Names
Target Protein Sequence
MADLAENVSL PLSQESFEDL WKMNLNLVAV QPPETESWVG YDNFMMEAPL QVEFDPSLFE
VSATEPAPQP SISTLDTGSP PTSTVPTTSD YPGALGFQLR FLQSSTAKSV TCTYSPDLNK
LFCQLAKTCP VQIVVDHPPP PGAVVRALAI YKKLSDVADV VRRCPHHQST SENNEGPAPR
GHLVRVEGNQ RSEYMEDGNT LRHSVLVPYE PPQVGSECTT VLYNFMCNSS CMGGMNRRPI
LTIITLETQE GQLLGRRSFE VRVCACPGRD RKTEEINLKK QQETTLETKT KPAQGIKRAM
KEASLPAPQP GASKKTKSSP AVSDDEIYTL QIRGKEKYEM LKKFNDSLEL SELVPVADAD
KYRQKCLTKR VAKRDFGVGP KKRKKLLVKE EKSDSD
Uniprot No.
Target Background
Function
Acts as a tumor suppressor in many tumor types, inducing growth arrest or apoptosis depending on the physiological context and cell type. Involved in cell cycle regulation as a trans-activator, negatively regulating cell division by controlling genes required for this process. One activated gene inhibits cyclin-dependent kinases. Apoptosis induction may occur through BAX and FAS antigen stimulation or Bcl-2 repression.
Gene References Into Functions
High p53 levels in rainbow trout tissues and cell lines have been reported. Elevated p53 levels in gills may indicate a heightened need for checkpoint control in this tissue, which is likely exposed to genotoxic compounds in the aquatic environment (PMID: 21767662).
Database Links
UniGene: Omy.11581
Protein Families
P53 family
Subcellular Location
Cytoplasm. Nucleus.
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