Recombinant Organic solute transporter alpha-like protein C18A3.4 (C18A3.4)
Description
Overview of Organic Solute Transporters (OSTα/β)
OSTα (encoded by SLC51A) and OSTβ (encoded by SLC51B) form a heteromeric transporter critical for bile acid and steroid transport across basolateral membranes in enterocytes, hepatocytes, and renal cells . Key features include:
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Structure: OSTα is a 340-amino-acid polytopic membrane protein with seven transmembrane domains, while OSTβ is a 128-amino-acid single-pass membrane protein .
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Function: The OSTα-OSTβ complex facilitates sodium-independent transport of bile acids (e.g., taurocholate), estrone sulfate, and drugs (e.g., digoxin) .
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Localization: Expressed in the ileum, liver, kidney, and adrenal glands, with highest expression in the gastrointestinal tract .
Recombinant OSTα Proteins
While "C18A3.4" is not described in the provided sources, recombinant OSTα proteins have been studied for their role in bile acid transport and disease models:
Key Research Findings
OSTα/β in Drug Interactions
OSTα/β interacts with pharmaceuticals, impacting drug disposition and toxicity:
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Substrates: Taurocholate, estrone sulfate, dehydroepiandrosterone sulfate, and digoxin .
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Inhibitors: Glycochenodeoxycholic acid (cholestasis biomarker), troglitazone sulfate, and fidaxomicin .
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Clinical Relevance: OSTα/β overexpression in cholestatic liver diseases may exacerbate drug-induced hepatotoxicity .
Unresolved Questions and Research Gaps
Product Specs
Note: We prioritize shipping the format currently in stock. However, if you have specific format requirements, please indicate them during order placement. We will prepare accordingly.
Note: All proteins are shipped with standard blue ice packs. If you require dry ice shipping, please inform us in advance as additional fees will apply.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Target Background
KEGG: cel:CELE_C18A3.4
UniGene: Cel.6101
