Recombinant Pan troglodytes Sulfotransferase 6B1 (SULT6B1)
Description
Introduction to Recombinant Pan troglodytes Sulfotransferase 6B1 (SULT6B1)
Recombinant Pan troglodytes Sulfotransferase 6B1 (SULT6B1) is a cytosolic sulfotransferase enzyme derived from the chimpanzee (Pan troglodytes). Sulfotransferases are a family of enzymes involved in the phase II metabolism of drugs and endogenous compounds, primarily through the transfer of a sulfate group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to the target molecule. This process generally leads to increased water solubility and excretion of the metabolites.
Function and Expression of SULT6B1
SULT6B1 is part of the sulfotransferase family, which plays a critical role in detoxifying xenobiotics and metabolizing endogenous compounds. While the specific substrate for SULT6B1 has not been well-defined, its expression and activity are crucial for understanding its role in metabolism.
In humans, SULT6B1 is one of the less studied sulfotransferases, and its functional expression has been challenging due to structural issues . The lack of a complete N-terminal region complicates its purification and expression in bacterial systems, which are commonly used for recombinant protein production .
Table 1: Comparison of Human SULT Enzymes
Future Directions
Future research on Recombinant Pan troglodytes SULT6B1 should focus on overcoming the challenges associated with its expression and purification. This could involve developing novel expression systems or modifying the enzyme to improve stability and solubility. Additionally, identifying specific substrates for SULT6B1 would be crucial for understanding its metabolic role.
Given the limited availability of specific data on Recombinant Pan troglodytes SULT6B1, further studies are needed to elucidate its function, expression, and potential applications in drug metabolism and xenobiotic detoxification.
Product Specs
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Target Background
STRING: 9598.ENSPTRP00000020325
Q&A
Basic Research Questions
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What is SULT6B1 and what is its primary function in Pan troglodytes?
SULT6B1 (Sulfotransferase family 6B member 1) is part of the cytosolic sulfotransferase enzyme superfamily that catalyzes sulfate conjugation of various substrates. In chimpanzees, as in other mammals, SULT6B1 is likely involved in the metabolism of endogenous and xenobiotic compounds. This enzyme belongs to a family that is well conserved across mammals, fish, birds, and amphibians . The SULT family plays crucial roles in detoxification pathways and regulation of biological activities of various compounds through sulfation.
The mouse homologue of SULT6B1 metabolizes thyroxine and bithionol, suggesting similar substrate specificity may exist in Pan troglodytes . Unlike some other SULT enzymes, the SULT6B1 dimerization motif KXXXTVXXXE is not retained, indicating it likely exists as a monomer rather than a dimer .
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What is the genomic organization of SULT6B1 in Pan troglodytes?
The Pan troglodytes SULT6B1 gene has been identified in genomic studies focused on the divergence between chimpanzees and bonobos . While detailed genomic organization specific to chimpanzee SULT6B1 is not fully characterized in the search results, we know the gene exists in the Pan troglodytes genome and is homologous to its human counterpart.
The gene is protein-coding, as evidenced by its inclusion in genetic databases for Pan troglodytes . Comparative genomic analyses between chimpanzees and humans suggest that specific gene architecture may contribute to phenotypic differences between species, though SULT6B1 specifically was not highlighted as showing major divergence patterns .
