Recombinant Papio hamadryas Taste receptor type 2 member 9 (TAS2R9)
Description
Introduction to Recombinant Papio hamadryas Taste Receptor Type 2 Member 9 (TAS2R9)
Recombinant Papio hamadryas Taste Receptor Type 2 Member 9 (TAS2R9) is a laboratory-engineered protein derived from the bitter taste receptor gene TAS2R9 of the Hamadryas baboon (Papio hamadryas). This receptor belongs to the G protein-coupled receptor (GPCR) superfamily and is involved in detecting bitter compounds, playing roles in dietary adaptation and toxin avoidance . Recombinant production enables large-scale study of its structural, functional, and therapeutic properties .
Gene and Protein Features
Table 1: Key Recombinant TAS2R9 Products for Papio hamadryas
| Product Code | Host System | Purity | Application |
|---|---|---|---|
| CSB-CF714513ERJ | E. coli | ≥85% | Functional assays, drug delivery |
| CSB-EP714513ERJ1 | Mammalian cells | ≥85% | Structural studies |
Cancer Research
TAS2R9 is a stromal target in pancreatic ductal adenocarcinoma (PDAC). Conjugated liposomes targeting TAS2R9 selectively deliver drugs like CXCR2 inhibitors to cancer-associated fibroblasts (CAFs), reducing tumor growth by inhibiting the CXCL-CXCR2 axis .
Key Findings:
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Targeted Drug Delivery: TAS2R9-specific liposomes show high stromal colocalization in PDAC xenografts .
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Efficacy: CXCR2 inhibitor delivery via TAS2R9-targeted liposomes suppresses cancer cell proliferation .
Role in Primate Adaptation
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Gene Duplication: TAS2R9 underwent lineage-specific duplications in Cercopithecidae (Old World monkeys), including Papio hamadryas, correlating with dietary diversification .
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Diet-Driven Evolution: Folivorous colobines exhibit reduced TAS2R genes (20–28 intact genes) compared to omnivorous cercopithecines like baboons (27–36 genes), reflecting dietary toxin tolerance strategies .
Table 2: TAS2R Gene Repertoire in Primates
| Subfamily | Species | Intact TAS2R Genes | Dietary Preference |
|---|---|---|---|
| Cercopithecinae | Papio hamadryas | 27–36 | Omnivorous |
| Colobinae | Colobus polykomos | 20–26 | Folivorous |
Research Gaps and Future Directions
Product Specs
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Target Background
Gustducin-coupled receptor involved in the detection of bitter compounds within the oral cavity and gastrointestinal tract. It signals through PLCB2 and the calcium-regulated cation channel TRPM5.
