Recombinant Paracoccus denitrificans Large-conductance mechanosensitive channel (mscL)
Description
Primary Function
mscL acts as a safety valve during osmotic stress, releasing ions (e.g., K⁺, glutamate) to prevent cell lysis . Its activation depends on lateral membrane tension rather than extracellular pressure .
Chemical and Pharmacological Modulators
Antibiotics like SCH-79797 exploit mscL’s absence in eukaryotes, positioning it as a novel antimicrobial target .
Research Applications
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Mechanosensation Studies:
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Antimicrobial Development:
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Membrane Biophysics:
Key Research Findings
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Structural Insights: Archaeal MscL structures (e.g., Thermobifida fusca) inform gating models, though the open state remains unresolved .
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Functional Degeneracy: Coexistence with the glyoxylate cycle in P. denitrificans suggests metabolic flexibility under stress .
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Pharmacological Potential: mscL’s role in bacterial survival under osmotic stress positions it for therapeutic targeting .
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your format preference during order placement for customized preparation.
Note: All proteins are shipped with standard blue ice packs unless dry ice shipping is requested in advance. Additional fees apply for dry ice shipping.
If a specific tag type is required, please inform us; we will prioritize its development.
Target Background
KEGG: pde:Pden_2265
STRING: 318586.Pden_2265
