Recombinant Pisum sativum Cytochrome c oxidase subunit 2 (COX2)
Product Specs
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Target Background
Cytochrome c oxidase subunit 2 (COX2) is a component of cytochrome c oxidase (complex IV, CIV), the terminal enzyme in the mitochondrial electron transport chain. This enzyme drives oxidative phosphorylation, a crucial process for ATP production. The respiratory chain comprises three multi-subunit complexes: succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (complex III, CIII), and cytochrome c oxidase (complex IV, CIV). These complexes collaborate to transfer electrons from NADH and succinate to molecular oxygen, establishing an electrochemical gradient across the inner mitochondrial membrane. This gradient powers transmembrane transport and ATP synthase activity. COX2 plays a vital role in the final step, catalyzing the reduction of oxygen to water within the enzyme's binuclear center (BNC), composed of heme a3 and copper B (CuB). Electrons from reduced cytochrome c in the intermembrane space are transferred via the copper A center (CuA) and heme a to the BNC, where oxygen reduction occurs using four electrons from cytochrome c and four protons from the mitochondrial matrix.
