Recombinant Plasmodium vivax Flap endonuclease 1 (FEN1), partial
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder. We may ship a different format if available; however, special format requests can be made when ordering.
Lead Time
Delivery times vary by purchase method and location. Contact your local distributor for specific delivery information. Proteins are shipped with standard blue ice packs. Dry ice shipping is available upon request for an additional fee.
Notes
Avoid repeated freeze-thaw cycles. Working aliquots can be stored at 4°C for up to one week.
Reconstitution
Briefly centrifuge the vial before opening. Reconstitute protein in sterile deionized water to 0.1-1.0 mg/mL. Add 5-50% glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Default glycerol concentration is 50%.
Shelf Life
Shelf life depends on storage conditions, buffer components, temperature, and protein stability. Liquid form is generally stable for 6 months at -20°C/-80°C. Lyophilized form is generally stable for 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receiving. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing. If you require a specific tag, please let us know, and we will prioritize its development.
Synonyms
FEN1; PVX_000820Flap endonuclease 1; FEN-1; EC 3.1.-.-; Flap structure-specific endonuclease 1
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Protein Length
Partial
Purity
>85% (SDS-PAGE)
Species
Plasmodium vivax (strain Salvador I)
Target Names
Uniprot No.
Target Background
Function
Flap endonuclease 1 (FEN1) is a structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. It removes the 5'-overhanging flap generated during Okazaki fragment processing, leaving a nick for ligation. It also participates in long-patch base excision repair (LP-BER) by cleaving within AP site-terminated flaps. FEN1 stabilizes the genome by preventing flap structures that could lead to duplications or deletions. It has 5'-3' exonuclease activity on nicked/gapped DNA and exhibits RNase H activity. It's also involved in rDNA and mitochondrial DNA replication and repair.
Database Links
KEGG: pvx:PVX_000820
STRING: 5855.PVX_000820
Protein Families
XPG/RAD2 endonuclease family, FEN1 subfamily
Subcellular Location
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion.
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