Recombinant Podospora anserina Cytochrome c oxidase subunit 2 (COII)
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Target Background
Recombinant Podospora anserina Cytochrome c oxidase subunit 2 (COII): Background Information
COII is a component of cytochrome c oxidase (complex IV, CIV), the terminal enzyme in the mitochondrial electron transport chain (ETC). The ETC, comprised of three multi-subunit complexes (complexes II, III, and IV), facilitates oxidative phosphorylation. Electrons from NADH and succinate are transferred to molecular oxygen, generating an electrochemical gradient across the inner mitochondrial membrane. This gradient drives transmembrane transport and ATP synthase activity. COII plays a crucial role in this process, as cytochrome c oxidase catalyzes the reduction of oxygen to water. Electrons from reduced cytochrome c (in the intermembrane space) are transferred through the copper A center (CuA) of subunit 2 and heme A of subunit 1 to the binuclear center (BNC) in subunit 1. This BNC, consisting of heme A3 and copper B (CuB), reduces molecular oxygen to two water molecules, utilizing four electrons from cytochrome c and four protons from the mitochondrial matrix.
KEGG: pan:PoanfMp43
