Recombinant Podospora anserina Signal peptidase complex catalytic subunit SEC11 (SEC11)
Description
Overview of Recombinant Podospora anserina Signal Peptidase Complex Catalytic Subunit SEC11 (SEC11)
Recombinant Podospora anserina Signal Peptidase Complex Catalytic Subunit SEC11 (SEC11) is a protein expressed in E. coli and tagged with N-terminal His for purification and identification purposes . SEC11 is a catalytic subunit of the signal peptidase complex, which is an enzyme responsible for cleaving signal peptides from precursor proteins during protein translocation across the endoplasmic reticulum membrane . Podospora anserina is a filamentous fungus, used as a model organism in genetics and aging studies .
Gene Information
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Synonyms: SEC11; Pa_6_7190; PODANS_6_7190; Signal peptidase complex catalytic subunit SEC11; Signal peptidase I .
Functional Annotation and Significance
SEC11 is a crucial component of the signal peptidase complex, responsible for cleaving signal peptides from newly synthesized proteins that are destined for secretion or integration into cellular membranes . The signal peptidase complex is essential for protein processing and trafficking in eukaryotic cells.
Applications in Research
Recombinant SEC11 can be utilized in various research applications:
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** изучения энзиматических механизмов:** Studying the enzymatic mechanisms of signal peptide cleavage .
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** белок-белковые взаимодействия:** Investigating protein-protein interactions within the signal peptidase complex .
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** структурные исследования:** Conducting structural studies to understand the protein's architecture and function .
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** разработка ингибиторов:** Developing inhibitors that target SEC11 for potential therapeutic applications .
Podospora anserina as a Model Organism
Podospora anserina is a filamentous fungus used as a model organism to study genetics, particularly allorecognition and heterokaryon incompatibility, which involves regulated cell death when strains of unlike genotype fuse . It exhibits phenotypic senescence on solid medium but has an unlimited lifespan in submerged cultivation, making it valuable for studying adaptation and aging . P. anserina also produces hemicellulases that can enhance the saccharification of lignocellulosic biomass, showing its potential in industrial applications .
Data Table
Product Specs
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Target Background
The Recombinant Podospora anserina Signal Peptidase Complex Catalytic Subunit SEC11 (SEC11) is a catalytic component of the signal peptidase complex (SPC). It catalyzes the cleavage of N-terminal signal sequences from proteins destined for the endoplasmic reticulum (ER). This signal peptide cleavage occurs during, or after, translocation through the translocon pore into the ER.
KEGG: pan:PODANSg7671
STRING: 515849.XP_001910632.1
