Recombinant Prosthecochloris vibrioformis Phosphatidylserine decarboxylase proenzyme (psd)

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Cat. No.
BT39544
Source
Yeast
Synonyms
psd; Cvib_1400; Phosphatidylserine decarboxylase proenzyme; EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]
Purity
>85% (SDS-PAGE)
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Cat. No.
BT39544
Source
E.coli
Synonyms
psd; Cvib_1400; Phosphatidylserine decarboxylase proenzyme; EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]
Purity
>85% (SDS-PAGE)
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Cat. No.
BT39544
Source
E.coli
Synonyms
psd; Cvib_1400; Phosphatidylserine decarboxylase proenzyme; EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]
Purity
>85% (SDS-PAGE)
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Cat. No.
BT39544
Source
Baculovirus
Synonyms
psd; Cvib_1400; Phosphatidylserine decarboxylase proenzyme; EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]
Purity
>85% (SDS-PAGE)
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Cat. No.
BT39544
Source
Mammalian cell
Synonyms
psd; Cvib_1400; Phosphatidylserine decarboxylase proenzyme; EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]
Purity
>85% (SDS-PAGE)
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Description

Definition and Biological Origin

Recombinant Ctenus ornatus U10-ctenitoxin-Co1b is a synthetic version of the native U10-ctenitoxin-Co1b, a neurotoxin originally isolated from Ctenus ornatus (Brazilian wandering spider). It belongs to the ctenitoxin family, which targets ion channels or synaptic transmission mechanisms in prey organisms .

The recombinant form is expressed in Escherichia coli (E. coli), ensuring high purity (>85%) and reproducibility for research applications .

Expression System

  • Host: E. coli .

  • Expression Region: Residues 1–30 of the mature toxin .

  • Tag: Undisclosed tag added during manufacturing .

Purification

  • Purity: >85% verified by SDS-PAGE .

  • Reconstitution:

    • Solubilized in deionized sterile water (0.1–1.0 mg/mL).

    • Glycerol (5–50%) recommended for long-term storage .

Research Context and Applications

While direct functional studies of U10-ctenitoxin-Co1b are not provided in available sources, related cytogenetic research on Ctenus ornatus highlights:

  • Chromosomal Behavior: The species has a diploid chromosome number of 2n♂=28 (26+X1X2), with acrocentric chromosomes and conserved karyotypes across populations .

  • Venom Complexity: C. ornatus venom contains multiple neurotoxins, suggesting U10-ctenitoxin-Co1b may act synergistically with other components .

Limitations and Future Directions

  • Functional Data: Mechanisms of action, target receptors, and in vivo effects remain uncharacterized in publicly available literature.

  • Comparative Studies: Contrasting U10-ctenitoxin-Co1b with paralogs (e.g., U17-ctenitoxin-Co1a ) could reveal structure-activity relationships.

This recombinant toxin provides a foundation for neuropharmacological research, particularly in ion channel modulation, but requires further functional validation.

Product Specs

Form
Lyophilized powder. Note: We will preferentially ship the format we have in stock. If you have special format requirements, please note them when ordering, and we will fulfill your request.
Lead Time
Delivery time may vary based on purchasing method and location. Please consult your local distributors for specific delivery times. Note: All proteins are shipped with standard blue ice packs. For dry ice shipping, please contact us in advance; additional fees apply.
Notes
Avoid repeated freezing and thawing. Store working aliquots at 4°C for up to one week.
Reconstitution
Briefly centrifuge the vial before opening to collect contents at the bottom. Reconstitute the protein in sterile deionized water to a concentration of 0.1-1.0 mg/mL. We recommend adding 5-50% glycerol (final concentration) and aliquoting for long-term storage at -20°C/-80°C. Our default final glycerol concentration is 50% for your reference.
Shelf Life
Shelf life depends on several factors: storage conditions, buffer components, storage temperature, and protein stability. Generally, the liquid form has a shelf life of 6 months at -20°C/-80°C, and the lyophilized form has a shelf life of 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
The tag type will be determined during the manufacturing process. If you require a specific tag, please inform us, and we will prioritize developing it.
Synonyms
psd; Cvib_1400; Phosphatidylserine decarboxylase proenzyme; EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]
Buffer Before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-181
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris vibrioformis (strain DSM 265))
Target Names
psd
Target Protein Sequence
MFTPYGMSTL VKLAAVSVGT LLFSILLPLQ AAIPVGSAAA IFLIFSLWFF RDPNRSLPPG KGIVIAPADG TVMSIKACSH PFTGNGSSII SIFMSPLNVH VNRIPVTGTV TLLQHHPGSF SMAFDEKSGE ENERMEIGIE SNGMKLHFTQ VAGFLARRIV CPLSLNEPVT AGKRFGMIKF G
Uniprot No.
A4SG02

Target Background

Function
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
Database Links

KEGG: pvi:Cvib_1400

STRING: 290318.Cvib_1400

Protein Families
Phosphatidylserine decarboxylase family, PSD-A subfamily
Subcellular Location
Cell membrane; Peripheral membrane protein.

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