Recombinant Protochlamydia amoebophila GTPase Der (der)

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Cat. No.
BT2461181
Source
Yeast
Synonyms
der; engA; pc1480GTPase Der; GTP-binding protein EngA
Purity
>85% (SDS-PAGE)
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Cat. No.
BT2461181
Source
E.coli
Synonyms
der; engA; pc1480GTPase Der; GTP-binding protein EngA
Purity
>85% (SDS-PAGE)
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Cat. No.
BT2461181
Source
E.coli
Synonyms
der; engA; pc1480GTPase Der; GTP-binding protein EngA
Purity
>85% (SDS-PAGE)
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Cat. No.
BT2461181
Source
Baculovirus
Synonyms
der; engA; pc1480GTPase Der; GTP-binding protein EngA
Purity
>85% (SDS-PAGE)
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Cat. No.
BT2461181
Source
Mammalian cell
Synonyms
der; engA; pc1480GTPase Der; GTP-binding protein EngA
Purity
>85% (SDS-PAGE)
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Description

Scope of Available Research on Protochlamydia amoebophila

The provided sources detail the bacterium’s nucleotide transport systems, including:

  • NTT transporters (PamNTT1–5), which mediate ATP, GTP, UTP, CTP, and NAD+ exchange with host cells .

  • Inclusion membrane proteins, such as those interacting with RAB GTPases in Chlamydia trachomatis, though these are not directly linked to P. amoebophila .

Key Findings on NTTs:

TransporterSubstrate SpecificityTransport MechanismHost Interaction
PamNTT1ATP/ADP antiporterBidirectionalEnergy parasitism
PamNTT2CTP, GTP, ATP, UTPCounter-exchangeNucleotide pool balancing
PamNTT3UTPProton-coupled importRNA synthesis
PamNTT5GTP, ATP, GDPProton-driven importDNA/RNA synthesis
PamNTT4NAD+/ADP antiporterBidirectionalRedox cofactor acquisition

Absence of GTPase "Der" in Context

No studies in the provided sources mention a GTPase named "Der" or its recombinant form in P. amoebophila. Possible reasons include:

  • Nomenclature confusion: "Der" may refer to a hypothetical or misidentified gene/protein.

  • Specialized focus: Research on P. amoebophila prioritizes nucleotide transporters over GTPases, as the bacterium lacks de novo nucleotide synthesis .

  • Taxonomic overlap: Der GTPase might belong to a related species (e.g., Chlamydia trachomatis) but is not documented here.

Recommendations for Further Investigation

To address gaps in knowledge:

  1. Verify nomenclature: Confirm "Der" as the correct gene/protein name using NCBI or UniProt databases.

  2. Expand literature search:

    • Target journals specializing in Chlamydiae pathobiology or symbiosis.

    • Use keywords like Protochlamydia GTPase, Der gene, or recombinant GTPase.

  3. Functional genomics: Screen P. amoebophila’s genome for GTPase orthologs using tools like BLAST or KEGG.

Product Specs

Form
Lyophilized powder.
Note: While we prioritize shipping the format currently in stock, please specify your format preference during order placement for customized preparation.
Lead Time
Delivery times vary depending on the purchase method and location. Please contact your local distributor for precise delivery estimates.
Note: All proteins are shipped with standard blue ice packs unless dry ice shipping is requested in advance. Additional fees apply for dry ice shipping.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Centrifuge the vial briefly before opening to collect the contents. Reconstitute the protein in sterile, deionized water to a concentration of 0.1-1.0 mg/mL. For long-term storage, we recommend adding 5-50% glycerol (final concentration) and aliquoting at -20°C/-80°C. Our standard glycerol concentration is 50% and serves as a guideline.
Shelf Life
Shelf life depends on various factors, including storage conditions, buffer composition, temperature, and protein stability. Generally, liquid formulations have a 6-month shelf life at -20°C/-80°C, while lyophilized forms have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Upon receipt, store at -20°C/-80°C. Aliquoting is essential for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
Tag type is determined during manufacturing.
The tag type is determined during the production process. If you require a specific tag, please inform us, and we will prioritize its development.
Synonyms
der; engA; pc1480GTPase Der; GTP-binding protein EngA
Buffer Before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-487
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Protochlamydia amoebophila (strain UWE25)
Target Names
der
Target Protein Sequence
MTHLPKLAIV GRPNVGKSAL FNRICKQKIA IVDEAEGITR DRLYAEGELF GLHFQVIDTG GINARSKEVF NEEIKRQAEI AIEEADTIVQ VVDAHVGLTE LDKEVARVLL RTKKPVCLAV NKIDNLSQTS LMHQFHSLGI KQMIPVSAAQ GWQIAELLET AFEKISREIE SQETFSSIKV AIVGRANVGK SSLVNYLLDE DRCIVSPIPG TTRDSVDISF THKDECYTLI DTAGIRRKRA EHEVVDKFAA IRTERAIERA DLCVLMLDVQ EGITAQDKKI ANTIEEAGQG CIILLNKWDL VQGFRMEHCL QNLEEEVPFL RHCPKIFTSA KTGRNIDKLF PLIQEVYANS QKRITTHQLN KFIGEALQKN HPPMIQGKRL RIYYMAQVAV KPPKFILFVN YPNLMTDTYK KYLYNQFREA YAFTGVPILI HLKGKTKKDK PVSSLSLTRK QTKSTDQENN EYDELYQEQR VSDEDYYFEN EEDLTEK
Uniprot No.
Q6MB45

Target Background

Function
GTPase crucial for the late stages of ribosome biogenesis.
Database Links

KEGG: pcu:pc1480

STRING: 264201.pc1480

Protein Families
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, EngA (Der) GTPase family

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