Recombinant Psittacid herpesvirus 1 Serine/threonine-protein kinase UL13 (UL13)
Description
Introduction to Recombinant Psittacid Herpesvirus 1 Serine/threonine-protein kinase UL13 (UL13)
Recombinant Psittacid herpesvirus 1 Serine/threonine-protein kinase UL13 (UL13) is a protein kinase derived from Psittacid herpesvirus 1 (PsHV-1), which causes Pacheco's disease in psittacine birds. This enzyme belongs to the conserved herpesvirus protein kinase (CHPK) family, similar to other herpesvirus UL13 homologs like HSV pUL13, EBV pBGLF4, and HCMV pUL97 . The UL13 protein kinases play crucial roles in viral replication, transcription, translation, and immune evasion by phosphorylating various host and viral proteins.
Role in Immune Evasion
Herpesvirus UL13 homologs are known to evade the host immune response by inhibiting key signaling pathways. For example, they can phosphorylate and inhibit interferon regulatory factor 3 (IRF3), leading to reduced type I interferon production . Additionally, UL13 can promote the ubiquitination and degradation of host immune proteins, further impairing the host's ability to mount an effective antiviral response.
Research Findings and Data
While specific data on recombinant PsHV-1 UL13 is limited, studies on other herpesvirus UL13 homologs provide valuable insights into their functions and potential as therapeutic targets. The following table summarizes some key features of herpesvirus UL13 homologs:
References
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify any format requirements in your order notes for customized preparation.
Note: All proteins are shipped with standard blue ice packs. Dry ice shipping requires advance notice and incurs additional charges.
The specific tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
Target Background
KEGG: vg:2657010
