Recombinant Rabbitpox virus Late protein H7 homolog (RPXV094)
Description
Overview of Recombinant Rabbitpox Virus Late Protein H7 Homolog (RPXV094)
The Recombinant Rabbitpox virus Late protein H7 homolog (RPXV094) is a protein expressed by the Rabbitpox virus (RPXV), specifically during the late stage of the viral replication cycle . RPXV is a member of the Orthopoxvirus genus, which includes other notable viruses such as the variola virus (the causative agent of smallpox) and vaccinia virus . The H7 homolog protein is involved in the virus's life cycle, though its precise function is not fully elucidated .
Characteristics and Properties
Role in Viral Infection and Immunity
RPXV is highly lethal in rabbits, making it a useful model for studying poxvirus infections and potential therapeutic interventions . Studies indicate that RPXV can lethally infect young rabbits via intradermal routes even at low doses .
The antibody responses to Modified Vaccinia Ankara (MVA) and WR strains of viruses reveal that hyperimmune rabbit MVA sera mainly recognize late virion proteins, suggesting RPXV094 could be one of the key targets for antibody-mediated immunity .
Applications in Vaccine Development
Recombinant viruses, including swinepox virus, expressing viral proteins like VP60 from Rabbit Hemorrhagic Disease Virus (RHDV), have shown promise as effective vaccines in rabbits . The VP60 protein expressed by recombinant swinepox virus self-assembles into virus-like particles (VLPs), inducing high levels of neutralizing antibodies and protecting rabbits from lethal RHDV infection .
Experimental Models and Results
In a study, New Zealand White rabbits were challenged intradermally with RPXV to develop a therapeutic model for poxvirus infections . The time course from RPXV inoculation to abnormal parameters, such as fever, viremia, and pox lesions, and eventual death were closely monitored. Statistical analysis of these parameters revealed significant differences between 9-week-old and 16-week-old RPXV-infected rabbits .
| Parameter | 9-Week-Old Rabbits | 16-Week-Old Rabbits |
|---|---|---|
| Survival | Lower | Higher |
| Time to Fever | Longer | Shorter |
| Viremia | No significant difference | No significant difference |
| Pox Lesions | No significant difference | No significant difference |
| Time to Death | No significant difference | No significant difference |
Product Specs
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Target Background
Contributes to the formation of crescents and immature virions (IV).
