Recombinant Rat Gap junction alpha-1 protein (Gja1)

1. Intracellular Ca2+ signals and Cx43 hemichannel opening are crucial steps in regulating Thy-1-induced astrocyte migration. PMID: 30049932
2. Studies have investigated the multiple phosphorylation-dependent roles of the carboxyl terminus in Cx43 channel gating and permeation. PMID: 29867029
3. beta;-catenin directly interacts with the Cx43 carboxyl-terminal domain. PMID: 29882937
4. Treatment with various concentrations of PDGF increased the levels of phosphorylated protein kinase B (AKT), beta-catenin, and Cx43, whereas inhibition of PDGFR or activation of phosphatidylinositol 3 kinase (PI3K)/AKT signaling altered b-catenin and Cx43 expression. PMID: 29174980
5. Cx43 expression was significantly upregulated in glomeruli of ORG rats compared to the control group. PMID: 29246788
6. Data suggests that mitochondrial Cx43 is involved in the apoptotic process in cardiomyocytes (using a chemical model of cell hypoxia in a cardiomyocyte cell line). Mitochondrial Cx43 appears to play a crucial role in cytoprotection/cardioprotection. PMID: 29155206
7. These findings indicate that Cx43 positively modulates osteogenic differentiation of Bone Marrow Stromal Cells by up-regulating GSK-3beta/beta-catenin signaling pathways. PMID: 29763908
8. The protein expression levels of hippocampal Cx36 and Cx43 during epileptogenesis in the pilocarpine model of epilepsy were examined. PMID: 28042145
9. Cx43 in the gap junctional channel may regulate lymphocyte activation and inflammatory cytokine production. PMID: 29115377
10. The ERK/MAPK signaling pathway may be involved in elevating cardiac Cx43 expression levels under glucose deprivation in H9c2 cells. PMID: 29115504
11. The osteogenic effect of dorsal root ganglion neurons on mesenchymal stem cells is mediated through the regulation of Cx43 and N-cadherin expression and activation of the canonical/beta-catenin Wnt signaling pathway. PMID: 29238079
12. In vitro gain and loss of function analyses showed that overexpression of Connexin 32 and knockdown of Connexin 43 promoted hepatocytes differentiation from hepatic progenitor cells. PMID: 29116012
13. Potentiation of Amitriptyline Anti-Hyperalgesic-Like Action By Astroglial Connexin 43 Inhibition in Neuropathic Rats. PMID: 27941941
14. WXKL protected the ultrastructure of the gap junctions and their constituent Cx43 by regulating miR-1 and PKC mediated signal transduction and increased the VFT significantly in the rat MI model. The results suggest that WXKL is an effective alternative medicine to prevent potentially lethal arrhythmia following MI. PMID: 29094045
15. The results indicate that VEGF promotes endothelial progenitor cell differentiation and vascular repair through Cx43. PMID: 29065929
16. Results indicate strain and species differences in Cx36 as well as Cx45 expression, possible compensatory processes after loss of Cx36 expression and localization of Cx45 to both neuronal and Bergmann glial gap junctions. Expression of both Cx43 and Cx45 in Bergmann glia of rat may contribute to the complex properties of junctional coupling between these cells and perhaps to their reported coupling with Purkinje cells. PMID: 28561933
17. Myocardial Cx43 is most likely implicated in potentially salutary responses to acute heart injury. PMID: 28459162
18. Data suggest that ischemic preconditioning (IPC)-induced cardioprotection involves increased nitric oxide (NO)production, protein kinase C epsilon (PKC-epsilon) translocation, connexin43 (Cx43) phosphorylation, and chemical gap junction (GJ) uncoupling. PMID: 27655723
19. Recruitment of Csk and PTEN to the region between residues 266 and 283 within the C-terminus of Cx43 leads to c-Src inhibition in glioma cells and astrocytes. PMID: 27391443
20. Hypoxic postconditioning with siRNA targeting connexin 43 or the reactive oxidative species scavengers superoxide dismutase plus catalase significantly prevented reactive oxidative specie generation and cardioprotection. These data strongly supported the involvement of connexin 43 in HPC cardioprotection. PMID: 29179175
21. Histological analysis revealed extravasation of erythrocytes, and immunohistochemical analysis showed alteration of the pattern of the gap-junction protein connexin 43. PMID: 29121655
22. Ezrin associates with Cx43 (in complex with ZO-1) which places PKA in proximity to Cx43, enabling its phosphorylation and gap junction opening. PMID: 28077322
23. Our study indicates that Cx43 hemichannels promote the disassembly of cell junctions through regulation of intracellular oxidative status. PMID: 27567473
24. Cx43 and Smad1 promote BMP2-induced cartilage differentiation of bone marrow mesenchymal stem cells and inhibit osteoblast differentiation, providing a new strategy for cartilage tissue engineering using exogenous Cx43 and Smad1. PMID: 28697500
25. Cx43 hemichannels contribute to smooth muscle cell Ca(2+ )dynamics and contractility, by facilitating Ca(2+ )entry, ATP release, and purinergic signaling. PMID: 27677282
26. In conclusion, AVP-mediated vascular contractile effects are endothelium and myoendothelial gap junction independent. Gap junctions between VSMCs, gap junctional communication, and Cx43 phosphorylation at Ser(262) play important roles in the vascular effects of AVP. RhoA/ROCK, but not PKC, is involved in this process. PMID: 28974518
27. Based on these findings, we propose that Cx43 was the Cx isoform involved in MEGJ-mediated VEC-dependent regulation of Ang-2, which induces iNOS protein expression and vascular hyporeactivity after hypoxia. PMID: 28637680
28. High levels of SGSM3 appeared to induce the turnover of Cx43 through lysosomal degradation in myocardial infarcted rat hearts. PMID: 28716730
29. A plaque accretion defect as the primary manifestation of myosin VI loss in Cx43 homeostasis is reported. PMID: 28096472
30. Study demonstrated that recombinant tissue plasminogen activator-induced hemorrhagic transformation in cerebral ischemia is closely related to an increase in p-Cx43 through the activation of the PI3K and ERK pathways. PMID: 27138645
31. Cx43 plays a proapoptotic role in cisplatin-induced auditory cell death in both junctional and nonjunctional conditions. Targeting the Cx-mediated signaling control may be helpful in designing new therapeutic strategies for drug-induced ototoxicity. PMID: 27122099
32. Our findings demonstrate that Na-K-ATPase regulates intercellular communication in the vascular wall via cSrc-dependent Cx43 tyrosine phosphorylation. PMID: 28122732
33. Cx43 expression plays a role in intercellular electrical coupling. PMID: 28034749
34. These findings indicate that, similar to Src, Tyk2 can also inhibit gap junction communication by phosphorylating Cx43. PMID: 27235399
35. Internalization of Cx43 into the cytoplasm occurred during ischemia, which was partially mediated through endocytosis. PMID: 28424784
36. FA also relaxed the mesenteric arterioles by reducing the expression of Cx43, which decreased blood pressure. Therefore, regulation of the expression of GJs may be a therapeutic target for the treatment of hypertension. PMID: 27748857
37. There is an inverse relationship between expression of cardiac Cx43 and the levels of circulating thyroid hormones. PMID: 27643942
38. Ischemic postconditioning can inhibit the up-regulation of miRNA-1 induced by ischemia-reperfusion, and the down-regulation of miRNA-1 can prevent the decrease and redistribution of Cx43. PMID: 28081514
39. Neuronal Cx36 plays a role in rhythmic firing in substantia gelatinosa of rat neonatal dorsal horn in vitro. PMID: 27462070
40. Thus, miR-206 and Cx43 are involved in the repair of exercise-induced muscle injury. PMID: 27706732
41. Cx43 can communicate cyclic AMP (cAMP) between cells and, more importantly, the communicated cAMP is sufficient to impact signal transduction cascades and the expression of key bone effector molecules between interconnected cells. PMID: 27156839
42. Tiaogan Qingxin Granule reduced the myocardial infarct size, lowered the myocardial infarction rate, and increased Cx43 expression, possibly by increasing blood supply to the cardiac muscles. In conclusion, Tiaogan Qingxin Granule may be useful for treating ischemic PVB. PMID: 27323125
43. This study demonstrated that altered Cx43 expression modulates bFGF expression, which correlates with prolactinoma development. PMID: 27078698
44. The propagation of satellite glial cell activation throughout the trigeminal ganglion via gap junctions, which are composed of connexin 43, plays a pivotal role in ectopic mechanical hypersensitivity in whisker pad skin following inferior alveolar nerve injury. PMID: 27030716
45. Phosphorylation of connexin43 serine-368 is necessary to maintain conduction velocity during metabolic stress. PMID: 26459193
46. These data indicate a fine regulation of the gap junction channel make-up in function of the type and the ratio of co-expressed connexins that specifically regulates chemical and electrical coupling. PMID: 26550940
47. Cx43 is involved in the development of vascular RS. PMID: 26398676
48. MG132 may be used to prevent degradation of Cx43 in heart failure, and thus may prevent Cx43-mediated arrhythmia. PMID: 26398314
49. Findings suggest that overexpression of connexin 43 (Cx43) reinitiated spermatogenesis at least through the steps of meiosis to generate round spermatids in testes. PMID: 26678449
50. Ovariectomized rats showed frequent bladder contraction and increased connexin-43 expression without changes in M2 and M3 receptor expression. PMID: 25647175

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KEGG: rno:24392

STRING: 10116.ENSRNOP00000001054

UniGene: Rn.10346