Recombinant Rat GRAM domain-containing protein 1A (Gramd1a)
Description
Introduction to Recombinant Rat GRAM Domain-Containing Protein 1A (Gramd1a)
Recombinant Rat GRAM domain-containing protein 1A (Gramd1a) is a protein encoded by the Gramd1a gene and is involved in cellular response to cholesterol . Gramd1a contains a GRAM domain, which is a protein module that binds to sterols, particularly cholesterol, and phosphoinositides . Gramd1a influences various cellular processes, including tumor growth and chemotherapy resistance .
Gene and Protein Information
The Gramd1a gene encodes a protein involved in cholesterol binding and transfer activity . Gramd1a has been identified as a key gene with potential therapeutic targets . Studies show that Gramd1a is upregulated in several types of cancer, suggesting its possible use as a biomarker .
Functional Analysis and Research Findings
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Role in Hepatocellular Carcinoma (HCC): Gramd1a is upregulated in HCC tissues, and high levels of Gramd1a are associated with poor patient outcomes . Gramd1a promotes self-renewal of HCC stem cells, resistance to chemotherapy, and tumor growth by regulating signal transducer and activator of transcription 5 (STAT5) .
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Role in Wilms Tumor (WT): Gramd1a is highly expressed in WT tissues, and its expression is associated with tumor progression . Silencing Gramd1a inhibits cell viability, proliferation, migration, and invasion in WT cells, indicating its potential as a therapeutic target .
GRAMD1A Expression and Clinical Significance
GRAMD1A and JAK/STAT Signaling Pathway
GRAM domain-containing protein 1B (GRAMD1B) is positively regulated by JAK/STAT signaling, and GRAMD1B inhibition decreases STAT3 levels, suggesting a positive feedback loop . GRAMD1B and JAK/STAT signaling act synergistically to promote gastric cancer cell survival by upregulating the expression of the anti-apoptotic molecule Bcl-xL .
ER-PM Contact Sites
GRAM domain proteins, particularly GRAMD2a, control the localization and translocation of STIM1 proteins . GRAMD2a is involved in setting up and regulating $$Ca^{2+}$$ signaling by mediating endoplasmic reticulum–plasma membrane (ER-PM) contact sites .
Product Specs
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