Recombinant Rat Transmembrane Protein 106C, also known as Tmem106c, is a protein that has been engineered for research purposes. This protein is derived from the rat version of the transmembrane protein 106C, which is part of a larger family of transmembrane proteins involved in various cellular processes. The recombinant form of this protein allows researchers to study its functions and interactions in a controlled environment.
Cell Cycle Regulation: TMEM106C is involved in cell cycle progression, promoting proliferation and metastasis in cancer cells .
Gene Interactions: TMEM106C interacts with genes like CENPM and DLC-1, influencing cancer cell behavior .
Targeting TMEM106C: Inhibiting TMEM106C could offer a novel therapeutic strategy for treating cancers, including overcoming resistance to certain drugs .
The recombinant rat Tmem106c is used in research settings to study its biological functions and potential applications. While specific studies on this recombinant protein are scarce, it is likely used to explore mechanisms similar to those observed in human TMEM106C, such as cell cycle regulation and cancer progression.
Given the limited specific data available for recombinant rat Tmem106c, we can refer to general findings related to TMEM106C in cancer research:
| Cancer Type | TMEM106C Expression | Clinical Implication |
|---|---|---|
| HCC | Overexpressed | Poor prognosis |
| Other cancers | Overexpressed in many | Promotes proliferation |
KEGG: rno:315286
UniGene: Rn.99883