Recombinant Rhodopirellula baltica UvrABC system protein B (uvrB), partial
Description
Molecular Context and Functional Role
UvrABC System Overview
The UvrABC endonuclease complex is a conserved bacterial DNA repair system comprising three subunits:
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UvrA: ATPase responsible for lesion recognition
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UvrB: Helicase that unwinds DNA and verifies damage
In Rhodopirellula baltica, the recombinant UvrB fragment retains partial functionality, enabling studies on its interaction with UvrA and damaged DNA substrates. This system is critical for maintaining genomic integrity under oxidative stress, as demonstrated in related species like Mycobacterium tuberculosis .
Research Applications
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Mechanistic Studies: Used to dissect the NER pathway in understudied Planctomycetes .
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Biotechnological Tools: Serves as a template for engineering thermostable DNA repair enzymes.
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Antimicrobial Targets: Inhibition of UvrB could sensitize bacteria to DNA-damaging agents .
Genomic and Ecological Context
Rhodopirellula baltica’s genome encodes 7,325 genes, many involved in polysaccharide degradation and environmental adaptation . While UvrB is not directly linked to these pathways, its role in stress resistance highlights the organism’s survival strategies in marine ecosystems.
Product Specs
Note: We will prioritize shipping the format currently in stock. However, if you have any specific requirements for the format, please specify your preference when placing the order. We will prepare the product according to your request.
Note: All of our proteins are shipped with standard blue ice packs. If you require dry ice shipping, please inform us in advance as additional fees will apply.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Target Background
KEGG: rba:RB8397
STRING: 243090.RB8397
