Recombinant Saguinus imperator Melanocyte-stimulating hormone receptor (MC1R)
Description
MC1R Overview
The melanocortin 1 receptor (MC1R) is a G protein-coupled receptor (GPCR) critical for regulating melanogenesis, skin pigmentation, and UV-induced DNA repair . Activation by α-MSH stimulates cAMP signaling, promoting eumelanin synthesis and enhancing genomic stability . Loss-of-function MC1R variants are linked to fair skin, UV sensitivity, and melanoma risk in humans .
Research Findings in Tamarins
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Platy-1 Retroposons: Saguinus genomes exhibit extensive Platy-1 retroposon amplification, which may influence genomic evolution but has no direct link to MC1R function .
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MC1R Polymorphisms: While human MC1R variants are well-studied, tamarin MC1R research focuses on structural conservation. For example, S. midas MC1R shares 85% amino acid identity with human MC1R .
Applications and Implications
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Melanoma Research: MC1R dysfunction correlates with UV sensitivity and impaired DNA repair (e.g., nucleotide excision repair) .
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Pharmacological Targeting: MC1R agonists (e.g., synthetic melanocortins) are explored for melanoma prevention by enhancing pigmentation and DNA repair .
Comparative Analysis of MC1R in Primates
Unresolved Questions
Product Specs
Note: While we prioritize shipping the format currently in stock, we are happy to accommodate your specific format requirements. Please clearly indicate your preference when placing your order, and we will prepare the product accordingly.
Note: All our proteins are shipped standard with blue ice packs. If you require dry ice shipment, please communicate with us beforehand, as additional fees will apply.
Generally, liquid forms have a shelf life of 6 months at -20°C/-80°C. Lyophilized forms typically have a shelf life of 12 months at -20°C/-80°C.
