Recombinant Salmonella paratyphi A 1-deoxy-D-xylulose-5-phosphate synthase (dxs), partial

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Cat. No.
BT2434077
Source
Yeast
Synonyms
dxs; SPA23011-deoxy-D-xylulose-5-phosphate synthase; EC 2.2.1.7; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS
Purity
>85% (SDS-PAGE)
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Cat. No.
BT2434077
Source
E.coli
Synonyms
dxs; SPA23011-deoxy-D-xylulose-5-phosphate synthase; EC 2.2.1.7; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS
Purity
>85% (SDS-PAGE)
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Cat. No.
BT2434077
Source
E.coli
Synonyms
dxs; SPA23011-deoxy-D-xylulose-5-phosphate synthase; EC 2.2.1.7; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS
Purity
>85% (SDS-PAGE)
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Cat. No.
BT2434077
Source
Baculovirus
Synonyms
dxs; SPA23011-deoxy-D-xylulose-5-phosphate synthase; EC 2.2.1.7; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS
Purity
>85% (SDS-PAGE)
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Cat. No.
BT2434077
Source
Mammalian cell
Synonyms
dxs; SPA23011-deoxy-D-xylulose-5-phosphate synthase; EC 2.2.1.7; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS
Purity
>85% (SDS-PAGE)
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Description

Introduction to Recombinant Salmonella paratyphi A 1-Deoxy-D-Xylulose-5-Phosphate Synthase (DXS)

Recombinant Salmonella paratyphi A 1-deoxy-D-xylulose-5-phosphate synthase (DXS), partial, refers to a genetically engineered version of the DXS enzyme from Salmonella paratyphi A. The DXS enzyme is crucial in the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, which is responsible for producing isoprenoids in bacteria. Isoprenoids are essential for various cellular functions, including membrane synthesis and the production of quinones.

Role of DXS in the MEP Pathway

DXS catalyzes the first step in the MEP pathway, converting pyruvate and glyceraldehyde-3-phosphate (GAP) into 1-deoxy-D-xylulose-5-phosphate (DXP) through a transketolase-like decarboxylation reaction . This pathway is vital for the synthesis of isoprenoids, which are necessary for bacterial growth and survival.

Significance of Recombinant DXS

Recombinant DXS enzymes are used in research to study the MEP pathway and its regulation. By manipulating the expression of DXS, researchers can alter the flux through the MEP pathway, affecting the production of downstream isoprenoids. This is particularly relevant in understanding bacterial metabolism and developing strategies to inhibit bacterial growth by targeting essential pathways.

Data Tables

EnzymeSubstratesProductPathway
DXSPyruvate, GAPDXPMEP pathway

References

- PMC: Functional Characterization of the 1-Deoxy-D-Xylulose 5-Phosphate...
- ASM: Molecular and Cellular Characterization of a Salmonella enterica...
- PMC: Integrated use of biochemical, native mass spectrometry, computational and genome-editing methods to elucidate the mechanism of a Salmonella deglycase
- JXB: Functional characterization of the three genes encoding 1-deoxy-D...
- Microbiology Research: The genomic characterization of Salmonella Paratyphi A from an...

Product Specs

Form
Lyophilized powder
Note: While we will prioritize shipping the format currently in stock, please specify any format requirements in your order notes for customized fulfillment.
Lead Time
Delivery times vary depending on the purchasing method and location. Please contact your local distributor for precise delivery estimates.
Note: All proteins are shipped with standard blue ice packs unless dry ice shipping is requested. Please contact us in advance to arrange dry ice shipping; additional fees will apply.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Centrifuge the vial briefly before opening to collect the contents. Reconstitute the protein in sterile, deionized water to a concentration of 0.1-1.0 mg/mL. We recommend adding 5-50% glycerol (final concentration) and aliquoting for long-term storage at -20°C/-80°C. Our standard glycerol concentration is 50% and can serve as a guideline.
Shelf Life
Shelf life depends on various factors, including storage conditions, buffer composition, temperature, and the protein's inherent stability. Generally, liquid formulations have a 6-month shelf life at -20°C/-80°C, while lyophilized forms have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Upon receipt, store at -20°C/-80°C. Aliquot for multiple uses to prevent repeated freeze-thaw cycles.
Tag Info
Tag type is determined during the manufacturing process.
The specific tag type is determined during production. If a particular tag is required, please inform us, and we will prioritize its incorporation.
Synonyms
dxs; SPA23011-deoxy-D-xylulose-5-phosphate synthase; EC 2.2.1.7; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS
Buffer Before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Datasheet
Please contact us to get it.
Protein Length
Partial
Purity
>85% (SDS-PAGE)
Species
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Target Names
dxs
Uniprot No.
Q5PFR6

Target Background

Function
This enzyme catalyzes the acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate, resulting in the production of 1-deoxy-D-xylulose-5-phosphate (DXP).
Database Links

KEGG: spt:SPA2301

Protein Families
Transketolase family, DXPS subfamily

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