Recombinant Schizosaccharomyces pombe Uncharacterized derlin-like protein C1687.17c (SPAC1687.17c)
Description
Overview of Recombinant Schizosaccharomyces pombe Uncharacterized Derlin-Like Protein C1687.17c (SPAC1687.17c)
Recombinant Schizosaccharomyces pombe Uncharacterized Derlin-Like Protein C1687.17c (SPAC1687.17c) is a genetically engineered protein derived from the fission yeast Schizosaccharomyces pombe. This protein is classified as a member of the Der1-like (degradation in the ER) family, which is implicated in endoplasmic reticulum-associated degradation (ERAD) processes . The recombinant form is produced for research applications, including functional studies and protein interaction assays .
Predicted Role in ER-Associated Degradation
SPAC1687.17c shares homology with Der1-like proteins, which are critical for ERAD—a quality-control mechanism that targets misfolded proteins for proteasomal degradation . While its exact substrate specificity remains uncharacterized, structural similarities suggest involvement in substrate recognition or translocation .
Genetic and Proteomic Studies
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Gene Deletion Phenotype: Deletion of SPAC1687.17c in S. pombe is viable, indicating it is non-essential under standard laboratory conditions .
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Protein Interaction Network:
Role in Fission Yeast Research
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Plasmid Construction: SPAC1687.17c studies benefit from S. pombe’s advanced genetic tools, including recombination-based plasmid engineering .
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Proteomic Profiling: Comparative proteomics in S. pombe has identified secretory pathway limitations, providing context for optimizing recombinant protein yields .
Future Directions
Current gaps include resolving SPAC1687.17c’s precise mechanistic role in ERAD and its interaction partners during stress conditions. Advances in S. pombe proteomics and CRISPR-based editing could accelerate functional characterization .
Product Specs
Please note: We will prioritize shipping the format currently in stock. However, if you require a specific format, please indicate your preference in the order notes. We will fulfill your request if available.
Note: All of our proteins are shipped with standard blue ice packs by default. If dry ice shipping is required, please inform us in advance. Additional fees will apply.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Target Background
KEGG: spo:SPAC1687.17c
STRING: 4896.SPAC1687.17c.1
