Recombinant Serpentine receptor class delta-2 (srd-2)
Description
Key Properties:
Functional and Biological Context
While the endogenous role of srd-2 in C. elegans remains less characterized compared to other serpentine receptors (e.g., srd-25 ), GPCRs in this nematode are broadly implicated in chemosensation, synaptic plasticity, and developmental signaling . For example:
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Serpentine receptors in C. elegans regulate responses to mechanical, thermal, and chemical cues .
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Mutations in related receptors (e.g., sdn-1) disrupt Wnt-dependent spindle orientation during embryogenesis .
The recombinant srd-2 protein enables researchers to study its ligand-binding properties and signaling mechanisms in vitro, though direct functional data for srd-2 remain limited .
Research Applications
Recombinant srd-2 is primarily utilized as a reagent for:
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Antibody Production: Generating antibodies for immunohistochemistry or Western blotting .
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Pathway Analysis: Investigating GPCR-mediated signaling cascades in heterologous systems.
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Structural Studies: Mapping receptor domains involved in ligand interactions .
Notably, C. elegans serpentine receptors are evolutionarily conserved, making srd-2 a proxy for studying human GPCR dysfunction linked to diseases like cancer or neurodegeneration .
Challenges and Future Directions
Current limitations include the lack of full-length srd-2 constructs and validated ligands. Future studies could:
Product Specs
Please note: We will prioritize shipping the format currently in stock. However, if you have specific requirements for the format, please indicate them in your order notes, and we will prepare your order accordingly.
Note: All our proteins are shipped with standard blue ice packs. If you require dry ice shipping, please inform us in advance as additional fees may apply.
Generally, liquid forms have a shelf life of 6 months at -20°C/-80°C. Lyophilized forms have a shelf life of 12 months at -20°C/-80°C.
Target Background
KEGG: cel:CELE_R05H5.1
UniGene: Cel.28758
