Recombinant Sphingomonas wittichii UPF0391 membrane protein Swit_2334 (Swit_2334)
Product Specs
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Generally, liquid forms have a shelf life of 6 months at -20°C/-80°C. Lyophilized forms have a shelf life of 12 months at -20°C/-80°C.
Target Background
KEGG: swi:Swit_2334
STRING: 392499.Swit_2334
Q&A
Basic Research Questions
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What is the structural characterization of the Sphingomonas wittichii UPF0391 membrane protein Swit_2334?
Swit_2334 is a 60-amino acid membrane protein from Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) with UniProt accession number A5V8S7. Its amino acid sequence is mLKWALIFLVVGLVLGALGFGGIGGAFVGLAKILFFIAIALFIVFALLALFAGKKISDSI, which indicates a highly hydrophobic transmembrane structure . The protein belongs to the UPF0391 family, a group of uncharacterized proteins with potential membrane-associated functions. Structural analyses suggest it contains transmembrane helices consistent with its role as an integral membrane protein.
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What is the genomic context of Swit_2334 in the Sphingomonas wittichii RW1 genome?
Swit_2334 is positioned within a specific region of the S. wittichii RW1 genome. According to IslandPath analysis, it is located in a genomic context with distinctive G+C content characteristics. The protein-coding gene is surrounded by several other genes including those encoding metabolic enzymes and hypothetical proteins . The genomic neighborhood of Swit_2334 includes genes like Swit_2333 and Swit_2335, which may have functional relationships with Swit_2334 based on their proximity and potential co-regulation patterns. The genomic context analysis indicates it may be part of a functional gene cluster involved in membrane-associated processes.
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How does Swit_2334 expression change under different environmental conditions?
Transcriptomic analysis has revealed that Swit_2334 expression is significantly upregulated (16.0-fold increase) under specific environmental stress conditions . Studies have shown that the expression of this membrane protein varies depending on growth conditions, particularly in response to water stress and exposure to aromatic pollutants like dibenzofuran. When S. wittichii RW1 is grown in contaminated environments, Swit_2334 shows distinctive expression patterns compared to growth under standard laboratory conditions, suggesting its potential role in adaptation to environmental stressors or xenobiotic compounds .
