Recombinant Theropithecus gelada Cytochrome c oxidase subunit 2 (MT-CO2)
Description
Introduction to Cytochrome c Oxidase Subunit 2 (MT-CO2)
Cytochrome c oxidase subunit 2 (MT-CO2) is a crucial component of the mitochondrial electron transport chain, specifically within Complex IV. This enzyme plays a pivotal role in the process of oxidative phosphorylation, where it facilitates the transfer of electrons from cytochrome c to oxygen, ultimately contributing to the production of ATP, the primary energy currency of cells.
Structure and Function of MT-CO2
MT-CO2 is one of the three mitochondrial-encoded subunits of cytochrome c oxidase, alongside MT-CO1 and MT-CO3. These subunits are integral to the enzyme's function, which involves the reduction of oxygen to water, a process that drives the proton gradient necessary for ATP synthesis.
Assembly and Regulation of Cytochrome c Oxidase
The assembly of cytochrome c oxidase involves a complex series of steps, including the incorporation of mitochondrial-encoded subunits like MT-CO2, along with nuclear-encoded subunits and various co-factors. This process is highly regulated and involves numerous assembly factors that ensure the proper formation and function of the enzyme complex .
Relevance to Gelada Biology
While specific research on recombinant Theropithecus gelada MT-CO2 is lacking, studies on geladas have focused on their unique dietary adaptations and environmental responses. Geladas are graminivorous, primarily consuming grasses, which requires efficient digestive processes. Their gut microbiome adjusts seasonally to optimize nutrient extraction from their diet, reflecting adaptations to environmental variability .
Research Findings and Implications
Research on geladas highlights their ability to adapt to changing environmental conditions, such as shifts in rainfall and temperature, which affect their diet and energy metabolism . While not directly related to MT-CO2, these studies demonstrate the importance of understanding how environmental factors influence metabolic processes in geladas.
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized fulfillment.
Note: Standard shipping includes blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
The tag type is determined during production. To prioritize a specific tag, please inform us during your order placement.
Target Background
Cytochrome c oxidase subunit 2 (MT-CO2) is a crucial component of cytochrome c oxidase (Complex IV), the terminal enzyme in the mitochondrial electron transport chain (ETC). The ETC, comprising Complexes I-IV, facilitates oxidative phosphorylation by transferring electrons from NADH and succinate to molecular oxygen. This process generates a proton gradient across the inner mitochondrial membrane, driving ATP synthesis. Within Complex IV, MT-CO2 contributes to the dinuclear copper A center (CuA) and facilitates electron transfer from reduced cytochrome c (in the intermembrane space) to the binuclear center (BNC). The BNC, comprised of heme a3 and copper B (CuB), catalyzes the reduction of oxygen to water, utilizing four electrons from cytochrome c and four protons from the mitochondrial matrix.
