Recombinant Uncharacterized protein Rv0874c/MT0897 (Rv0874c, MT0897)
Description
General Information
Rv0874c/MT0897 is an uncharacterized protein from Mycobacterium tuberculosis . Creative BioMart offers Rv0874c/MT0897 proteins for life science research and states that all products are rigorously tested .
Table 1: Recombinant Rv0874c/MT0897 Product Details
| Cat.# | Product Name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RFL24795HF | Recombinant Full Length Uncharacterized Protein Rv0874C/Mt0897 (Rv0874C, Mt0897) Protein, His-Tagged | E. coli | Human | His | Full Length (1-386) | N/A |
Function and Pathways
The uncharacterized protein Rv0874c/MT0897 is involved in several pathways and has different roles, and it has several biochemical functions . Rv0874c/MT0897 interacts directly with proteins and molecules, and these interactions have been detected through methods like yeast two-hybrid assays, co-IP, and pull-down assays .
Rv0792c as a HutC Homolog
Rv0792c is a HutC homolog from Mycobacterium tuberculosis . A strain of M. tuberculosis with a Rv0792c mutant was compromised for survival upon exposure to oxidative stress and infection in guinea pigs, when compared to the parental strain . RNA sequencing analysis has shown that Rv0792c regulates the expression of genes involved in stress adaptation and virulence of M. tuberculosis .
Rv0792c and GntR Transcription Factors
Rv0792c belongs to the HutC subfamily of GntR transcription factors . M. tuberculosis has seven GntR homologs (Rv0043c, Rv0165c, Rv0494, Rv0586, Rv0792c, Rv1152, and Rv3060c), and multiple-sequence alignment revealed that these share almost identical residues in the DNA binding amino-terminal region . Rv0792c shares an identity of ~30% with other HutC homologs . Residues Arg49 and Gly80 of Rv0792c are important for DNA binding .
Table 2: Binding Affinity of Rv0792c Mutants
| Protein | Kd Value (nM) |
|---|---|
| Wild-type | ~51 |
| Rv0792c R49A | ~74 |
| Rv0792c G80D | ~120 |
Product Specs
Note: While we prioritize shipping the format currently in stock, specific format requests should be noted during order placement to ensure fulfillment.
Note: Proteins are shipped with standard blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
The specific tag type is determined during production. If you require a specific tag, please inform us, and we will prioritize its development.
