Recombinant UPF0299 membrane protein YPTB1529 (YPTB1529)
Description
Despite limited direct studies, YPTB1529’s structural features align with outer membrane protein (OMP) dynamics observed in related systems:
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Membrane Protein Assembly: The BAM (β-barrel assembly machinery) complex, critical for OMP biogenesis, demonstrates sequential substrate recognition . While YPTB1529 is not directly linked to BAM, its membrane localization suggests potential interactions with such systems.
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Dynamics and Stability: Solid-state NMR studies on Klebsiella pneumoniae OmpA reveal β-barrel motions and loop flexibility, which may parallel YPTB1529’s structural behavior .
Current applications likely focus on:
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Antibody Development: ELISA-grade recombinant proteins (e.g., 50 µg quantities) support serological studies .
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Structural Biology: Full-length His-tagged versions enable crystallization or cryo-EM studies to resolve transmembrane conformations .
Comparative Analysis with Related Proteins
While YPTB1529 lacks homologs with annotated functions, its UPF0299 classification suggests conserved membrane roles. Key distinctions:
| Feature | YPTB1529 | General OMPs (e.g., OmpC, OmpA) |
|---|---|---|
| Length | 135 aa | Varies (e.g., 300–400 aa) |
| Tag | His-tag (N-terminal) | Varies (e.g., GST, MBP) |
| Expression Host | E. coli, cell-free | E. coli, yeast, insect cells |
| Functional Data | Hypothetical | Transport, adhesion, immune evasion |
Product Specs
Note: While we prioritize shipping the format currently in stock, please specify your format preference in order notes for customized fulfillment.
Note: All proteins are shipped with standard blue ice packs. Dry ice shipping requires prior arrangement and incurs additional charges.
The tag type is determined during production. If you require a specific tag, please inform us; we will prioritize its development.
Target Background
KEGG: ypo:BZ17_986
