Recombinant Varicella-zoster virus Envelope glycoprotein I (gI)
Product Specs
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Target Background
In epithelial cells, the gE/gI heterodimer is crucial for cell-to-cell viral spread. It facilitates the targeting of nascent virions to cell junctions, enabling rapid spread to adjacent cells via interactions with junctional cellular receptors. This process is implicated in basolateral spread within polarized cells. In neuronal cells, gE/gI is essential for anterograde spread throughout the nervous system. In conjunction with US9, gE/gI participates in the sorting and transport of viral structural components to axon terminals.
The gE/gI heterodimer functions as a receptor for the Fc region of human IgG. Its dissociation from IgG occurs at acidic pH. This suggests a potential role in interfering with host antibody-mediated immune responses through bipolar bridging of anti-VZV antibodies, followed by intracellular endocytosis and degradation.
KEGG: vg:1487689
