Recombinant Xenopus laevis SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (smarcb1)
Description
Function and Role of SMARCB1 in Chromatin Remodeling
SMARCB1, also known as SNF5/INI1/BAF47, is a core subunit of the SWI/SNF complex. This complex is essential for relieving repressive chromatin structures, thereby facilitating access for the transcriptional machinery to its targets . In mammals, SMARCB1 has been identified as a tumor suppressor, with mutations associated with malignant rhabdoid tumors . The SWI/SNF complex, including SMARCB1, is critical for enhancer regulation, particularly in activating differentiation-related enhancers .
Cancer and Tumor Suppression
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Tumor Suppression: SMARCB1 acts as a tumor suppressor in various cancers. Its loss is associated with tumorigenesis, particularly in rhabdoid tumors .
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Osteosarcoma: Weak SMARCB1 expression in osteosarcoma correlates with poor chemosensitivity and prognosis, suggesting its potential as a diagnostic and prognostic biomarker .
Recombinant SMARCB1 in Xenopus laevis
While specific studies on recombinant Xenopus laevis SMARCB1 are not readily available, its recombinant form would likely retain similar functions to its mammalian counterparts, including roles in chromatin remodeling and enhancer regulation. The use of recombinant proteins in research often involves studying their structure, function, and interactions in a controlled environment.
Potential Applications and Future Research Directions
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Cancer Research: Understanding the mechanisms of SMARCB1 in cancer could lead to novel therapeutic strategies targeting chromatin remodeling complexes.
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Developmental Biology: Studying SMARCB1 in Xenopus laevis could provide insights into developmental processes and how chromatin remodeling influences cell fate decisions.
Data Tables
Given the lack of specific data on recombinant Xenopus laevis SMARCB1, we can consider general data related to SMARCB1 functions and its role in cancer:
| Cancer Type | SMARCB1 Expression | Clinical Significance |
|---|---|---|
| Rhabdoid Tumors | Loss of Expression | Tumorigenesis |
| Osteosarcoma | Weak Expression | Poor Prognosis |
| Epithelioid Sarcoma | Loss of Expression | Diagnostic Biomarker |
Product Specs
Target Background
This protein is involved in chromatin remodeling as a core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays crucial roles in cell proliferation and differentiation, antiviral cellular activities, and tumor suppression. It is a constituent of both the neural progenitors-specific chromatin remodeling complex (npBAF) and the neuron-specific chromatin remodeling complex (nBAF), potentially contributing to neural development.
KEGG: xla:443934
UniGene: Xl.44271
