Recombinant Xenopus laevis Tripartite motif-containing protein 72 (trim72)
Shipped with Ice Packs 
In Stock 
Product Specs
Form
Lyophilized powder
Note: While we will prioritize shipping the format currently in stock, please specify any format requirements in your order notes for customized preparation.
Note: While we will prioritize shipping the format currently in stock, please specify any format requirements in your order notes for customized preparation.
Lead Time
Delivery times vary depending on the purchase method and location. Please contact your local distributor for precise delivery estimates.
Note: All proteins are shipped with standard blue ice packs unless otherwise requested. Dry ice shipping requires prior arrangement and incurs additional charges.
Note: All proteins are shipped with standard blue ice packs unless otherwise requested. Dry ice shipping requires prior arrangement and incurs additional charges.
Notes
Avoid repeated freeze-thaw cycles. Store working aliquots at 4°C for up to one week.
Reconstitution
Centrifuge the vial briefly before opening to collect the contents. Reconstitute the protein in sterile, deionized water to a concentration of 0.1-1.0 mg/mL. We recommend adding 5-50% glycerol (final concentration) and aliquoting for long-term storage at -20°C/-80°C. Our standard glycerol concentration is 50% and may serve as a guideline for your preparation.
Shelf Life
Shelf life depends on various factors, including storage conditions, buffer composition, temperature, and protein stability. Generally, liquid formulations have a 6-month shelf life at -20°C/-80°C, while lyophilized forms have a 12-month shelf life at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses to prevent repeated freeze-thaw cycles.
Tag Info
Tag type is determined during the manufacturing process.
The specific tag type is determined during production. If you require a particular tag, please inform us, and we will prioritize its development.
The specific tag type is determined during production. If you require a particular tag, please inform us, and we will prioritize its development.
Synonyms
trim72; mg53; Tripartite motif-containing protein 72; Mitsugumin-53; Mg53
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-477
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Xenopus laevis (African clawed frog)
Target Names
trim72
Target Protein Sequence
MSTPQLMQGM QKDLTCQLCL ELFRAPVTPE CGHTFCQGCL TGVPKNQDQN GSTPCPTCQS
PSRPETLQIN RQLEHLVQSF KQVPQGHCLE HMDPLSVYCE QDKELICGVC ASLGKHKGHN
IITASEAFAK LKRQLPQQQV ILQEARLKKE KTVAVLDRQV AEVQDTVSRF KGNVKHQLNA
MRSYLNIMEA SLGKEADKAE SAATEALLVE RKTMGHYLDQ LRQMEGVLKD VEGQEQTEFL
RKYCVVAARL NKILSESPPP GRLDIQLPII SDEFKFQVWR KMFRALMPAL ENMTFDPDTA
QQYLVVSSEG KSVECADQKQ SVSDEPNRFD KSNCLVSKQS FTEGEHYWEV IVEDKPRWAL
GIISETANRK GKLHATPSNG FWIIGCKEGK VYEAHTEQKE PRVLRVEGRP EKIGVYLSFS
DGVVSFFDSS DEDNLKLLYT FNERFSGRLH PFFDVCWHDK GKNSQPLKIF YPPAEQL
Uniprot No.
Target Background
Function
A muscle-specific protein crucial for cell membrane repair. It functions by nucleating the assembly of the repair machinery at injury sites, specifically binding to phosphatidylserine. It acts as an oxidation sensor; membrane damage and subsequent exposure to extracellular oxidative environments induce disulfide bond formation and homooligomerization at the injury site. This oligomerization serves as a nucleation point for recruiting TRIM72-containing vesicles, leading to membrane patch formation and likely preceding Ca(2+)-dependent membrane resealing.
Database Links
KEGG: xla:379612
UniGene: Xl.24124
Protein Families
TRIM/RBCC family
Subcellular Location
Cell membrane, sarcolemma. Cytoplasmic vesicle membrane.
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