Recombinant Xenopus tropicalis TP53-regulated inhibitor of apoptosis 1 (triap1)
Shipped with Ice Packs 
In Stock 
Description
Functional Role in Apoptosis Regulation
TRIAP1 interacts with PRELID family proteins to facilitate phosphatidylserine (PS) and phosphatidic acid (PA) transport, critical for maintaining mitochondrial membrane integrity . Key findings include:
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Antiapoptotic Activity: TRIAP1 overexpression inhibits cytochrome c release, reducing susceptibility to apoptosis under mild genotoxic stress .
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p53 Pathway Interaction: Acts as a p53-responsive survival factor, antagonizing p21-mediated cell-cycle arrest .
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Cancer Relevance: Elevated TRIAP1 levels correlate with tumorigenesis in colorectal cancer models, where its knockdown activates p53 and suppresses mTORC1 signaling .
Recombinant Production and Applications
Commercially available recombinant TRIAP1 proteins are optimized for research applications:
Research Implications
Studies using recombinant TRIAP1 have revealed:
Product Specs
Form
Lyophilized powder. We will preferentially ship the format we have in stock. If you have special format requirements, please note them when ordering, and we will fulfill your request.
Lead Time
Delivery times vary depending on the purchase method and location. Please consult your local distributor for specific delivery information. All proteins are shipped with standard blue ice packs. For dry ice shipping, please contact us in advance; additional fees apply.
Notes
Avoid repeated freezing and thawing. Store working aliquots at 4°C for up to one week.
Reconstitution
Briefly centrifuge the vial before opening to collect the contents at the bottom. Reconstitute the protein in sterile deionized water to a concentration of 0.1-1.0 mg/mL. Adding 5-50% glycerol (final concentration) and aliquoting for long-term storage at -20°C/-80°C is recommended. Our default final glycerol concentration is 50% for your reference.
Shelf Life
Shelf life depends on several factors, including storage conditions, buffer components, storage temperature, and protein stability. Generally, the liquid form has a shelf life of 6 months at -20°C/-80°C, while the lyophilized form has a shelf life of 12 months at -20°C/-80°C.
Storage Condition
Store at -20°C/-80°C upon receipt. Aliquot for multiple uses. Avoid repeated freeze-thaw cycles.
Tag Info
The tag type will be determined during the manufacturing process. If you require a specific tag, please inform us, and we will prioritize developing it.
Synonyms
triap1; TP53-regulated inhibitor of apoptosis 1; p53-inducible cell-survival factor; p53csv
Buffer Before Lyophilization
Tris/PBS-based buffer, 6%
Trehalose.
Datasheet
Please contact us to get it.
Expression Region
1-78
Protein Length
full length protein
Purity
>85% (SDS-PAGE)
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Target Names
triap1
Target Protein Sequence
MNSVGEECTD MKREYDQCFN RWFAEKFLKG ECSGDPCTEL FRRYRDCVQK AIKDKDIPVD
GVDFMGPSKS KTESDGSS
Uniprot No.
Target Background
Function
Triap1 modulates the mitochondrial apoptotic pathway by ensuring cardiolipin (CL) accumulation in mitochondrial membranes. The triap1:prelid1 complex likely acts as a phosphatidic acid (PA) transporter across the mitochondrial intermembrane space, providing PA for cardiolipin synthesis in the inner membrane. Similarly, the triap1:prelid3a complex mediates PA transfer between liposomes (in vitro) and likely functions as a PA transporter across the mitochondrial intermembrane space (in vivo). Triap1 promotes cell survival by inhibiting caspase-9 activation, preventing apoptosis. It is essential for pronephros development, likely playing an early role in forming pronephric components from the somatic layer.
Database Links
Protein Families
TRIAP1/MDM35 family
Subcellular Location
Mitochondrion. Mitochondrion intermembrane space.
Tissue Specificity
Expressed in the developing pronephros.
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