REM19 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
REM19 antibody; RTV1 antibody; At1g49480 antibody; F13F21.8 antibody; B3 domain-containing protein REM19 antibody; Protein RELATED TO VERNALIZATION 1 antibody; Protein REPRODUCTIVE MERISTEM 19 antibody
Target Names
REM19
Uniprot No.
Target Background
Function
REM19 Antibody is involved in the regulation of vernalization. It binds to DNA in vitro in a non-sequence-specific manner. XLG2 enhances the DNA binding activity of RTV1, specifically targeting promoter regions of FT and SOC1 in vivo. This interaction leads to the activation of floral integrator genes.
Database Links
Subcellular Location
Nucleus.
Tissue Specificity
Ubiquitous.
Q&A
Based on the provided search results, no relevant information about "REM19 Antibody" was identified in the scientific literature or clinical research records. The cited studies discuss other monoclonal antibodies (e.g., MW05, MW07) and general immunogenicity testing methodologies, but no data exist for REM19 in these sources. Below is a template structure for antibody research FAQs that could be adapted if additional information becomes available:
Advanced Research Questions
What strategies mitigate Fc-mediated enhancement risks in REM19 development?
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Introduce LALA mutations (Leu234Ala/Leu235Ala) to eliminate FcγR binding while retaining neutralization capacity
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Compare ADE activity in THP-1 vs. Raji cell lines with flow cytometry quantification
How to resolve discrepancies between binding assays and functional neutralization data?
| Discrepancy Source | Resolution Approach |
|---|---|
| Conformational epitopes | Cryo-EM structural validation |
| ACE2 expression levels | Parallel testing in 293T (high ACE2) vs. A549 (low ACE2) |
Methodological Considerations
Standardizing immunogenicity assessments for REM19 clinical trials
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