RIN3 Antibody, FITC conjugated
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
We typically dispatch products within 1-3 business days of receiving your order. Delivery times may vary depending on the method of purchase and destination. Please consult your local distributors for specific delivery timelines.
Synonyms
RIN3 antibody; Ras and Rab interactor 3 antibody; Ras interaction/interference protein 3 antibody
Target Names
RIN3
Uniprot No.
Target Background
Function
RIN3 is a Ras effector protein that functions as a guanine nucleotide exchange factor (GEF) for RAB5B and RAB31. It facilitates the exchange of bound GDP for free GTP, which is essential for the normal function of RAB31.
Gene References Into Functions
- RIN3 may play a role in endolysosomal transport, a process known to be important in the development of early-onset Alzheimer's disease. PMID: 28738127
- RIN3 may contribute to susceptibility to Paget's disease of bone by influencing osteoclast function. PMID: 25701875
- Studies have identified novel interaction candidates for CD2AP and characterized subtle but significant differences in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3. PMID: 26296892
- Research has revealed a novel association between a variant within RIN3 and lower limb bone mineral density, reinforcing its previously established association with the risk of Paget's disease. PMID: 24945404
- RIN3 acts as a negative regulator of mast cell responses to SCF. PMID: 23185384
- RIN3 specifically functions as a GEF for Rab31. PMID: 21586568
- RIN3 has been biochemically characterized as the stimulator and stabilizer for GTP-Rab5. This interaction plays a crucial role in the transport pathway from the plasma membrane to early endosomes. PMID: 12972505
- Tyrosine phosphorylation signals are involved in the activation and translocation of RIN3 to early endocytic vesicles. PMID: 18486601
Database Links
Protein Families
RIN (Ras interaction/interference) family
Subcellular Location
Cytoplasm. Cytoplasmic vesicle. Early endosome.
Tissue Specificity
Widely expressed.
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