RPL21M Antibody

RPL21 Overview

RPL21 is a 19–25 kDa ribosomal protein encoded by the RPL21 gene (NCBI Gene ID: 6144). It plays a role in ribosome assembly and translation fidelity. Dysregulation of RPL21 is linked to cancer progression, including colorectal cancer (CRC) and pancreatic cancer (PC), where it promotes metastasis, cell proliferation, and apoptosis resistance .

Table 1: Selected RPL21 Antibodies

Role in Colorectal Cancer (CRC)

• Expression: RPL21 is upregulated in CRC tissues compared to normal counterparts (p < 0.01) .

• Mechanism:

  • Binds LAMP3 (lysosome-associated membrane protein 3) to stabilize FAK/paxillin/ERK signaling, promoting focal adhesion (FA) formation and metastasis .

  • Enhances LAMP3 stability by suppressing ubiquitin–proteasome degradation .

• Prognostic Value: High RPL21 correlates with poor survival in CRC patients .

Role in Pancreatic Cancer (PC)

• Functional Impact:

  • Silencing RPL21 via siRNA inhibits cell proliferation, induces G1 arrest, and triggers caspase-8-mediated apoptosis .

  • Downregulates MCM2-7 proteins and cyclins (CCND1, CCNE1), critical for DNA replication .

• Therapeutic Potential: RPL21 siRNA reduces tumor growth in murine models .

Table 2: Common Protocols for RPL21 Antibodies