Rmdn3 Antibody
Description
Research Applications and Mechanistic Insights
RMDN3 Antibodies are employed to study RMDN3’s roles in cellular processes, including:
ER-Mitochondria Interactions and Lipid Radical Transfer
RMDN3 interacts with VAPB (VAMP-associated protein B) at ER-mitochondria contact sites (MERCs) to mediate lipid radical transfer under oxidative stress. Knockdown studies using RMDN3 antibodies confirmed that this interaction is critical for scavenging mitochondrial lipid radicals, thereby preventing cell death .
Apoptosis and Calcium Homeostasis
RMDN3 regulates apoptosis via interactions with microtubules and calcium signaling pathways. Overexpression of RMDN3 induces apoptosis, a process that can be studied using antibodies to track protein localization and activity .
Cancer Research
RMDN3 is implicated in carcinomas (e.g., prostate, squamous cell) and benign hyperplasia. Antibodies enable detection of RMDN3 expression in tumor tissues, aiding in understanding its role in disease progression .
Critical Considerations for Use
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Specificity: Polyclonal antibodies may bind non-specific epitopes; validation via immunoprecipitation or immunoblotting is essential.
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Cross-reactivity: Mouse and rat homologs share 80–84% sequence identity with human RMDN3 .
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Applications: Optimal for studying RMDN3 in cellular models but not validated for diagnostic use .
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- PTPIP51, the gene encoding Rmdn3 Antibody, has been identified as a potential therapeutic target for ischemic heart diseases. PMID: 28345618
- The protein interaction profile of PTPIP51 suggests its involvement in memory formation in the hippocampus and cerebellum. PMID: 25496818
- PTPIP51 may act as a linking protein in adipocyte metabolism by connecting the insulin receptor-triggered lipogenesis with the protein kinase A-dependent lipolysis. PMID: 23533724
- The interaction of PTPIP51 with 14-3-3beta, particularly in trained individuals, hints at a role for PTPIP51 in the downstream regulation of insulin action. PMID: 21266951
- Studies have identified an upstream ORF in the PTPIP51 gene, which functions to reduce protein levels by approximately 79%. PMID: 19372376
- Research findings suggest a role for PTPIP51 in neuronal homeostasis, axonal growth, and transport. PMID: 19844996
- PTPIP51 has been implicated in signaling cascades that regulate differentiation and apoptosis during eye development. PMID: 18084773
